دورية أكاديمية
Low‐Dose Tamoxifen Induces Significant Bone Formation in Mice
| العنوان: | Low‐Dose Tamoxifen Induces Significant Bone Formation in Mice |
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| المؤلفون: | Zhihui Xie, Cody McGrath, Jeyantt Sankaran, Maya Styner, Sarah Little‐Letsinger, Amel Dudakovic, Andre J vanWijnen, Janet Rubin, Buer Sen |
| المصدر: | JBMR Plus, Vol 5, Iss 3, Pp n/a-n/a (2021) |
| بيانات النشر: | Oxford University Press, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Orthopedic surgery LCC:Diseases of the musculoskeletal system |
| مصطلحات موضوعية: | CONDITIONAL KNOCKOUT, OSTEOCLAST, μCT, Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935 |
| الوصف: | ABSTRACT Use of the selective estrogen receptor modulator Tamoxifen (TAM) is a mainstay to induce conditional expression of Cre recombinase in transgenic laboratory mice. To excise β‐cateninfl/fl in 28‐day‐old male and female Prrx1‐CreER/β‐cateninfl/fl mice (C57BL/6), we utilized TAM at 150 mg/kg; despite β‐catenin knockout in MSC, we found a significant increase in trabecular and cortical bone volume in all genders. Because TAM was similarly anabolic in KO and control mice, we investigated a dose effect on bone formation by treating wild‐type mice (WT C57BL/6, 4 weeks) with TAM (total dose 0, 20, 40, 200 mg/kg via four injections). TAM increased bone in a dose‐dependent manner analyzed by micro–computed tomography (μCT), which showed that, compared to control, 20 mg/kg TAM increased femoral bone volume fraction (bone volume/total volume [BV/TV]) (21.6% ± 1.5% to 33% ± 2.5%; 153%, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2473-4039 |
| Relation: | https://doaj.org/toc/2473-4039 |
| DOI: | 10.1002/jbm4.10450 |
| URL الوصول: | https://doaj.org/article/9020362feb41477088f97aef70886d37 |
| رقم الأكسشن: | edsdoj.9020362feb41477088f97aef70886d37 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24734039 |
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| DOI: | 10.1002/jbm4.10450 |