دورية أكاديمية
Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells.
| العنوان: | Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells. |
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| المؤلفون: | Barbara Gajkowska, Beata Pajak, Arkadiusz Orzechowski |
| المصدر: | Folia Histochemica et Cytobiologica, Vol 46, Iss 2, Pp 129-135 (2008) |
| بيانات النشر: | Via Medica, 2008. |
| سنة النشر: | 2008 |
| المجموعة: | LCC:Cytology |
| مصطلحات موضوعية: | Cytology, QH573-671 |
| الوصف: | This review outlines the molecular events that accompany the anti-tumor action of parthenolide (PN). Parthenolide (PN) is naturally derived compound, isolated from plant Tanacetum parthenium. PN has been previously shown to withdraw cells from cell cycle or to promote cell differentiation, and finally to induce programmed cell death. Recent advances in molecular biology indicate that this sesquiterpene lactone might evoke the above-mentioned effects by indirect action on genes. PN was shown to inhibit NF-kappaB- and STATs-mediated antiapoptotic gene transcription. On one hand, the proapoptotic activity of PN includes stimulation of intrinsic apoptotic pathway with the higher level of intracellular ROS and modifications of Bcl-2 family proteins (conformational changes of Bak and Bax, Bid cleavage). On the other hand, PN amplifies the apoptotic signal through the sensitization of cancer cells to extrinsic apoptosis, induced by TNF-alpha. These effects are specific to tumor cells. Unique properties of PN make this agent a promising metabolic inhibitor to retard tumorigenesis and to suppress tumor growth. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0239-8508 1897-5631 |
| Relation: | http://czasopisma.viamedica.pl/fhc/article/view/4441; https://doaj.org/toc/0239-8508; https://doaj.org/toc/1897-5631 |
| DOI: | 10.5603/4441 |
| URL الوصول: | https://doaj.org/article/9088899008f049a999c9236efee22022 |
| رقم الأكسشن: | edsdoj.9088899008f049a999c9236efee22022 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 02398508 18975631 |
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| DOI: | 10.5603/4441 |