دورية أكاديمية
أعرض في EDS

Major adverse cardiovascular events and hyperuricemia during tuberculosis treatment.

التفاصيل البيبلوغرافية
العنوان: Major adverse cardiovascular events and hyperuricemia during tuberculosis treatment.
المؤلفون: Hong-Joon Shin, Joon-Young Yoon, Young-Ok Na, Jae-Kyeong Lee, Bo Gun Kho, Tae-Ok Kim, Yu-Il Kim, Sung-Chul Lim, Sae-Hee Jeong, Yong-Soo Kwon
المصدر: PLoS ONE, Vol 18, Iss 11, p e0294490 (2023)
بيانات النشر: Public Library of Science (PLoS), 2023.
سنة النشر: 2023
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: BackgroundHyperuricemia is common during tuberculosis (TB) treatment, especially in association with pyrazinamide (PZA). This study investigated the relationship between major adverse cardiovascular events (MACEs) and hyperuricemia during TB treatment.MethodsWe conducted a single-center retrospective cohort study. From January 2010 through June 2017, we assessed all consecutive TB patients at Chonnam National University Hospital in South Korea. Hyperuricemia was defined as serum uric acid levels exceeding 7.0 mg/dL (men) and 6.0 mg/dL (women).ResultsOf the 1,143 patients included, PZA was administered to 1,081 (94.6%), and hyperuricemia was detected in 941 (82.3%). Eight patients experienced MACEs. Multivariate analysis using logistic regression indicated that prior ischemic heart disease was associated with MACE development (OR,14.087; 95% CI,3.304-60.061; P < 0.000), while hyperuricemia was not (OR, 1.505; 95% CI, 0.184-12.299; P = 0.703). For patients without drug-resistant TB, the absence of hyperuricemia was associated with higher mortality (OR, 2.609; 95% CI, 1.066-6.389; P = 0.036), whereas hyperuricemia was associated with less worse outcomes (OR,0.316; 95% CI,0.173-0.576; P < 0.000).ConclusionsAlthough most patients treated with PZA developed hyperuricemia, it was not associated with MACE development. Hyperuricemia during TB treatment was associated with better outcomes, possibly due to consistent adherence to TB treatment.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
90924614
Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0294490&type=printable; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0294490&type=printable
DOI: 10.1371/journal.pone.0294490
URL الوصول: https://doaj.org/article/9092461474734f728723c43c5fdf3fdd
رقم الأكسشن: edsdoj.9092461474734f728723c43c5fdf3fdd
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
90924614
DOI:10.1371/journal.pone.0294490&type=printable