دورية أكاديمية
أعرض في EDS

Application of G-CSF in high-leukocyte acute myeloid leukemia is a poor prognostic factor

التفاصيل البيبلوغرافية
العنوان: Application of G-CSF in high-leukocyte acute myeloid leukemia is a poor prognostic factor
المؤلفون: Ping Weng, Shu Yang, Shujuan Xu, Shuxia Zhang, Yong Wu, Yuanzhong Chen
المصدر: Hematology, Vol 28, Iss 1 (2023)
بيانات النشر: Taylor & Francis Group, 2023.
سنة النشر: 2023
المجموعة: LCC:Diseases of the blood and blood-forming organs
مصطلحات موضوعية: Granulocyte colony-stimulating factor, acute myeloid leukemia, prognosis, Diseases of the blood and blood-forming organs, RC633-647.5
الوصف: ABSTRACTObjective To analyze the effect of granulocyte colony-stimulating factor (G-CSF) on outcomes in patients with acute myeloid leukemia (AML).Methods A total of 526 patients with AML in the Haematology Department were enrolled. They were divided into a G-CSF treatment group and a no G-CSF group according to whether G-CSF was administered in the induction chemotherapy period, with 355 cases in the G-CSF group and 171 cases in the no G-CSF group. Cox regression analysis and Kaplan-Meier curve analysis were used to analyze the effect of G-CSF on the first complete remission (CR1) phase and overall survival (OS). In addition, further analysis was performed based on an initial white blood cell count of 50 * 10^9/L.Results The application of G-CSF significantly shortened the CR1 phase and OS in patients with high leukocytes.Conclusions G/GM-CSF should be used with caution in patients with AML, especially those with high leukocytes.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 16078454
1607-8454
Relation: https://doaj.org/toc/1607-8454
DOI: 10.1080/16078454.2023.2220521
URL الوصول: https://doaj.org/article/909ac0c37bd04b71a41aca282a97309a
رقم الأكسشن: edsdoj.909ac0c37bd04b71a41aca282a97309a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:16078454
DOI:10.1080/16078454.2023.2220521