دورية أكاديمية
Application of G-CSF in high-leukocyte acute myeloid leukemia is a poor prognostic factor
العنوان: | Application of G-CSF in high-leukocyte acute myeloid leukemia is a poor prognostic factor |
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المؤلفون: | Ping Weng, Shu Yang, Shujuan Xu, Shuxia Zhang, Yong Wu, Yuanzhong Chen |
المصدر: | Hematology, Vol 28, Iss 1 (2023) |
بيانات النشر: | Taylor & Francis Group, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Diseases of the blood and blood-forming organs |
مصطلحات موضوعية: | Granulocyte colony-stimulating factor, acute myeloid leukemia, prognosis, Diseases of the blood and blood-forming organs, RC633-647.5 |
الوصف: | ABSTRACTObjective To analyze the effect of granulocyte colony-stimulating factor (G-CSF) on outcomes in patients with acute myeloid leukemia (AML).Methods A total of 526 patients with AML in the Haematology Department were enrolled. They were divided into a G-CSF treatment group and a no G-CSF group according to whether G-CSF was administered in the induction chemotherapy period, with 355 cases in the G-CSF group and 171 cases in the no G-CSF group. Cox regression analysis and Kaplan-Meier curve analysis were used to analyze the effect of G-CSF on the first complete remission (CR1) phase and overall survival (OS). In addition, further analysis was performed based on an initial white blood cell count of 50 * 10^9/L.Results The application of G-CSF significantly shortened the CR1 phase and OS in patients with high leukocytes.Conclusions G/GM-CSF should be used with caution in patients with AML, especially those with high leukocytes. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 16078454 1607-8454 |
Relation: | https://doaj.org/toc/1607-8454 |
DOI: | 10.1080/16078454.2023.2220521 |
URL الوصول: | https://doaj.org/article/909ac0c37bd04b71a41aca282a97309a |
رقم الأكسشن: | edsdoj.909ac0c37bd04b71a41aca282a97309a |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 16078454 |
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DOI: | 10.1080/16078454.2023.2220521 |