دورية أكاديمية
Architectural control of mesenchymal stem cell phenotype through nuclear actin
| العنوان: | Architectural control of mesenchymal stem cell phenotype through nuclear actin |
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| المؤلفون: | Janet Rubin, Andre J. van Wijnen, Gunes Uzer |
| المصدر: | Nucleus, Vol 13, Iss 1, Pp 35-48 (2022) |
| بيانات النشر: | Taylor & Francis Group, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Genetics LCC:Cytology |
| مصطلحات موضوعية: | mechanoresponse, mechanical-strain, mesenchymal stem cell, cofilin, arp2/3, formin, epigenetics, Genetics, QH426-470, Cytology, QH573-671 |
| الوصف: | There is growing appreciation that architectural components of the nucleus regulate gene accessibility by altering chromatin organization. While nuclear membrane connector proteins link the mechanosensitive actin cytoskeleton to the nucleoskeleton, actin’s contribution to the inner architecture of the nucleus remains enigmatic. Control of actin transport into the nucleus, plus the presence of proteins that control actin structure (the actin tool-box) within the nucleus, suggests that nuclear actin may support biomechanical regulation of gene expression. Cellular actin structure is mechanoresponsive: actin cables generated through forces experienced at the plasma membrane transmit force into the nucleus. We posit that dynamic actin remodeling in response to such biomechanical cues provides a novel level of structural control over the epigenetic landscape. We here propose to bring awareness to the fact that mechanical forces can promote actin transfer into the nucleus and control structural arrangements as illustrated in mesenchymal stem cells, thereby modulating lineage commitment. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1949-1034 1949-1042 19491034 |
| Relation: | https://doaj.org/toc/1949-1034; https://doaj.org/toc/1949-1042 |
| DOI: | 10.1080/19491034.2022.2029297 |
| URL الوصول: | https://doaj.org/article/90c25eff0d8a4ad19afa374dfd47e733 |
| رقم الأكسشن: | edsdoj.90c25eff0d8a4ad19afa374dfd47e733 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 19491034 19491042 |
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| DOI: | 10.1080/19491034.2022.2029297 |