دورية أكاديمية
Bioinformatics analysis of differentially expressed genes in irradiated non-small cell lung cancer
| العنوان: | Bioinformatics analysis of differentially expressed genes in irradiated non-small cell lung cancer |
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| المؤلفون: | LIU Xiaoqiang, MA Dexun, LIU Shufeng |
| المصدر: | Fushe yanjiu yu fushe gongyi xuebao, Vol 39, Iss 1, Pp 61-70 (2021) |
| بيانات النشر: | Science Press, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Nuclear and particle physics. Atomic energy. Radioactivity LCC:Medical physics. Medical radiology. Nuclear medicine |
| مصطلحات موضوعية: | radiation, non-small cell lung cancer, differentially expressed genes, bioinformatics, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798, Medical physics. Medical radiology. Nuclear medicine, R895-920 |
| الوصف: | To explore the effect of radiation on lncRNA gene expression in non-small cell lung cancer (NSCLC), we searched for lncRNA genes on the Y chromosome for radiation response in NSCLC from the Gene Expression Omnibus database and obtained the expression profile data chip named GSE147708. We then conducted multiple online database analyses: we used GEO2R to screen for differentially expressed genes, Database for Annotation, Visualization and Integrated Discovery online tool for Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis, string online website to build a protein interaction network, and then used Cytoscape software to obtain the hub genes; finally, we used Gene Expression Profiling Interactive Analysis (GEPIA) online tool to combine all of these with The Cancer Genome Atlas (TCGA) data for prognostic value analysis. Approximately 23 upregulated genes and 28 downregulated genes were screened, and the top 20 core genes were obtained by building protein networks. Prognostic analysis results showed that the four genes CCNA2, HIST1H2BH, HIST1H2BK, and HIST1H2BO were related to the prognostic survival of NSCLC. CCNA2 and HIST1H2BK have the functional characteristics of oncogene, which have a certain promotion on the occurrence and development of NSCLC (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Chinese |
| تدمد: | 1000-3436 |
| Relation: | http://www.fs.sinap.ac.cn/thesisDetails#10.11889/j.1000-3436.2021.rrj.39.010303&lang=zh; https://doaj.org/toc/1000-3436 |
| DOI: | 10.11889/j.1000-3436.2021.rrj.39.010303&lang=zh |
| DOI: | 10.11889/j.1000-3436.2021.rrj.39.010303 |
| URL الوصول: | https://doaj.org/article/90ef342cf26e4b049d1b8f1b3041a935 |
| رقم الأكسشن: | edsdoj.90ef342cf26e4b049d1b8f1b3041a935 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10003436 |
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| DOI: | 10.11889/j.1000-3436.2021.rrj.39.010303&lang=zh |