دورية أكاديمية
Rare Intracranial Multifocal Non-Germinomatous Germ Cell Tumor in an 18-Year-Old Male: A Case Report
| العنوان: | Rare Intracranial Multifocal Non-Germinomatous Germ Cell Tumor in an 18-Year-Old Male: A Case Report |
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| المؤلفون: | Nikolina Sesar, Bruno Splavski, Marija Gamulin, Krešimir Rotim |
| المصدر: | Acta Clinica Croatica, Vol 62., Iss 1, Pp 234-240 (2023) |
| بيانات النشر: | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Non-germinomatous germ cell tumor, intracranial, Alpha fetoprotein, Beta human chorionic gonadotropin, Biopsy, Chemotherapy, Medicine |
| الوصف: | Intracranial germ cell tumors are rare brain tumors that are distinguished based on their histology and selected tumor markers. Non-germinomatous germ cell tumors are a diverse group of such tumors having the poorest prognosis. Most commonly, they are located in the suprasellar and pineal regions. Since the exact treatment protocol has not yet been established, there is currently no standardized modality of management. We present a case of intracranial multifocal non-germinomatous germ cell tumor in an 18-year-old male, along with relevant literature review. We describe initial diagnostic and treatment procedures in a young adult presented with diplopia and ataxic gait. Neuroradiological findings and elevated alpha fetoprotein and beta chain of the human chorionic gonadotropin tumor markers indicated the possible mixed germ cell tumor. Chemotherapy regimen was adjusted accordingly, biopsy was not performed. The patient’s clinical condition improved significantly and his alpha fetoprotein values decreased remarkably after initiation of chemotherapy. In conclusion, initial evaluation with neuroimaging, tumor markers, and cytology from cerebrospinal fluid is important as guidance to further treatment and prognosis. In selected cases, biopsy may not be indicated to start adjuvant chemotherapy. We emphasize the importance of specific treatment modality selection based mainly on tumor markers, regardless of the precise histologic classification. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0353-9466 1333-9451 |
| Relation: | https://hrcak.srce.hr/file/443608; https://doaj.org/toc/0353-9466; https://doaj.org/toc/1333-9451 |
| DOI: | 10.20471/acc.2023.62.01.28 |
| URL الوصول: | https://doaj.org/article/910f88b2e3844b1994dd8f2d9ee35c69 |
| رقم الأكسشن: | edsdoj.910f88b2e3844b1994dd8f2d9ee35c69 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 03539466 13339451 |
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| DOI: | 10.20471/acc.2023.62.01.28 |