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In vivo antitumor effects of carboxymethyl chitosan-conjugated triptolide after oral administration

التفاصيل البيبلوغرافية
العنوان: In vivo antitumor effects of carboxymethyl chitosan-conjugated triptolide after oral administration
المؤلفون: Huahui Zeng, Xin Zhu, Qikang Tian, Yinyin Yan, Lan Zhang, Min Yan, Ruiqin Li, Xiaofang Li, Guoqiang Wang, Jinlian Ma, Yufang Su, Xiangbo Zhang, Linyu Ma, Zhenqiang Zhang, Xiangxiang Wu
المصدر: Drug Delivery, Vol 27, Iss 1, Pp 848-854 (2020)
بيانات النشر: Taylor & Francis Group, 2020.
سنة النشر: 2020
المجموعة: LCC:Therapeutics. Pharmacology
مصطلحات موضوعية: triptolide, carboxymethyl chitosan, oral administration, pancreatic cancer, toxicity, Therapeutics. Pharmacology, RM1-950
الوصف: The purpose of this study is to evaluate in vitro and in vivo antitumor efficacy and subacute toxicity of triptolide (TP) prodrug, a conjugate between TP and carboxymethyl chitosan (CC). The CCTP conjugate contained 4∼ wt % TP and displayed excellent aqueous solubility (5 mg/mL) as compared to the native TP (17 μg/mL). In vitro cytotoxicity of CCTP conjugate was evaluated by CCK8 assay against human pancreatic cancer (PC) cell lines, showing comparable the half maximal inhibitory concentration (IC50) values to the parent TP. In a mouse model of PC (BxPC-3), the CCTP conjugate administered orally (at dose levels as low as 0.2 mg TP equivalent/kg) showed comparable efficacy in reducing or eliminating xenograft tumor to the same dose of TP, but exhibited much lower subacute toxicity as seen in body weight loss and hematological toxicity.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1071-7544
1521-0464
10717544
Relation: https://doaj.org/toc/1071-7544; https://doaj.org/toc/1521-0464
DOI: 10.1080/10717544.2020.1770370
URL الوصول: https://doaj.org/article/a911d90a1df34ab883e4e118c9742b34
رقم الأكسشن: edsdoj.911d90a1df34ab883e4e118c9742b34
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:10717544
15210464
DOI:10.1080/10717544.2020.1770370