دورية أكاديمية
أعرض في EDS

The association of circulating bioenergetic metabolites with healthy human aging

التفاصيل البيبلوغرافية
العنوان: The association of circulating bioenergetic metabolites with healthy human aging
المؤلفون: C. Navas-Enamorado, X. Capo, A.M. Galmes-Panades, A. Ortega-Moral, A. Sánchez-Polo, L. Masmiquel, M. Torrens-Mas, P. Navas, M. Gonzalez-Freire
المصدر: Experimental Gerontology, Vol 194, Iss , Pp 112488- (2024)
بيانات النشر: Elsevier, 2024.
سنة النشر: 2024
المجموعة: LCC:Medicine
LCC:Biology (General)
مصطلحات موضوعية: Metabolites, TCA cycle, Aging, Lactic acid, Citric acid, Medicine, Biology (General), QH301-705.5
الوصف: Aging is an inevitable and gradual decline in several biological functions. Mitochondrial dysfunction is one of the most important hallmarks of aging. In this context, alterations in metabolites associated with mitochondrial dysfunction may serve as a significant biomarker. This study aimed to investigate the existence of a relationship between the key metabolites involved in bioenergetics metabolism and aging. 53 volunteers ranged 20–85 years participated in the study. We tested the association between different tricarboxylic acid (TCA) cycle metabolites, fatty acid metabolism, and amino acid metabolism with age, sex, body composition, and proxy markers of aging such as walking speed, grip strength and chair test. We found that lactic acid negatively correlated with age while several fatty acid metabolites, such as azelaic, sebacic, and linoleic acids, showed positive correlations with age (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1873-6815
Relation: http://www.sciencedirect.com/science/article/pii/S053155652400130X; https://doaj.org/toc/1873-6815
DOI: 10.1016/j.exger.2024.112488
URL الوصول: https://doaj.org/article/9182b6c49591497e84221e7ea862b67e
رقم الأكسشن: edsdoj.9182b6c49591497e84221e7ea862b67e
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:18736815
DOI:10.1016/j.exger.2024.112488