دورية أكاديمية
KUS121, an ATP regulator, mitigates chorioretinal pathologies in animal models of age-related macular degeneration
| العنوان: | KUS121, an ATP regulator, mitigates chorioretinal pathologies in animal models of age-related macular degeneration |
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| المؤلفون: | Yuki Muraoka, Yuto Iida, Hanako O. Ikeda, Sachiko Iwai, Masayuki Hata, Takeshi Iwata, Mao Nakayama, Nobuhiro Shimozawa, Yuko Katakai, Akira Kakizuka, Nagahisa Yoshimura, Akitaka Tsujikawa |
| المصدر: | Heliyon, Vol 4, Iss 5 (2018) |
| بيانات النشر: | Elsevier, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Cell biology, Neuroscience, Ophthalmology, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Age-related macular degeneration (AMD) is a leading cause of blindness among elderly people. The appearance of drusen is a clinical manifestation and a harbinger of both exudative and atrophic AMD. Recently, antibody-based medicines have been used to treat the exudative type. However, they do not restore good vision in patients. Moreover, no effective treatment is available for atrophic AMD. We have created small chemicals (Kyoto University Substances; KUSs) that act as ATP regulators inside cells. In the present study, we examined the in vivo efficacy of KUS121 in C-C chemokine receptor type 2-deficient mice, a mouse model of AMD. Systemic administration of KUS121 prevented or reduced drusen-like lesions and endoplasmic reticulum stress, and then substantially mitigated chorioretinal pathologies with significant preservation of visual function. Additionally, we confirmed that long-term oral administration of KUS121 caused no systemic complications in drusen-affected monkeys. ATP regulation by KUSs may represent a novel strategy in the treatment of drusen and prevention of disease progression in AMD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844017326579; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2018.e00624 |
| URL الوصول: | https://doaj.org/article/91d4eee18f4349b59397b63e4f0237f4 |
| رقم الأكسشن: | edsdoj.91d4eee18f4349b59397b63e4f0237f4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2018.e00624 |