دورية أكاديمية
Preventive effect of N-stearoylethanolamine on memory disorders, blood and brain biochemical parameters in rats with experimental scopolamine-induced cognitive impairment
| العنوان: | Preventive effect of N-stearoylethanolamine on memory disorders, blood and brain biochemical parameters in rats with experimental scopolamine-induced cognitive impairment |
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| المؤلفون: | T. M. Horid’ko, H. V. Kosiakova, A. G. Berdyshev, O. F. Meged, O. V. Onopchenko, V. M. Klimashevsky, О. S. Tkachenko, V. R. Bazylianska, V. O. Kholin, K. O. Peschana, S. A. Mykhalskiy, N. M. Hula |
| المصدر: | The Ukrainian Biochemical Journal, Vol 90, Iss 6, Pp 97-109 (2018) |
| بيانات النشر: | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Biochemistry LCC:Medicine LCC:Biology (General) |
| مصطلحات موضوعية: | acetylcholinesterase, catalase, cholesterol, glutathione peroxidase, N-stearoylethanolamine, nitrotyrosine, phospholipids, scopolamine, superoxide dismutase, TBARS, Biochemistry, QD415-436, Medicine, Biology (General), QH301-705.5 |
| الوصف: | The impairment of cognitive functions is the most studied medical and social problem nowadays. The aim of this study was to evaluate the protective effects of N-stearoylethanolamine (NSE) on memory state, blood and brain biochemical parameters in rats under scopolamine-induced cognitive impairment. The results of this study shown that NSE administration to rats per os (5 mg/kg, 5 days, during last 3 days NSE was administrated 20 min prior to scopolamine injection (1 mg/kg, once daily for 3 days, intraperitoneally)) prevented the development of memory impairment. In particular, NSE action was associated with the prevention of increase in acetylcholinesterase activity, changes in phospholipid, free and esterified cholesterol level in hippocampus and frontal cortex, and disruption in pro-/antioxidant balance in blood and studied brain sections. Considering the above mentioned biological effects, NSE is a promising drug candidate for integrative therapy of cognitive impairment of different profiles. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2409-4943 2413-5003 |
| Relation: | http://ukrbiochemjournal.org/wp-content/uploads/2018/11/Horidko_6.pdf; https://doaj.org/toc/2409-4943; https://doaj.org/toc/2413-5003 |
| DOI: | 10.15407/ubj90.06.097 |
| URL الوصول: | https://doaj.org/article/91e70a98c90f46b39c2595002c5954ac |
| رقم الأكسشن: | edsdoj.91e70a98c90f46b39c2595002c5954ac |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24094943 24135003 |
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| DOI: | 10.15407/ubj90.06.097 |