Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastoma

التفاصيل البيبلوغرافية
العنوان:	Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastoma
المؤلفون:	Anke Nijhuis, Arti Sikka, Orli Yogev, Lili Herendi, Cristina Balcells, Yurui Ma, Evon Poon, Clare Eckold, Gabriel N. Valbuena, Yuewei Xu, Yusong Liu, Barbara Martins da Costa, Michael Gruet, Chiharu Wickremesinghe, Adrian Benito, Holger Kramer, Alex Montoya, David Carling, Elizabeth J. Want, Yann Jamin, Louis Chesler, Hector C. Keun
المصدر:	Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
بيانات النشر:	Nature Portfolio, 2022.
سنة النشر:	2022
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	The prognosis of high-risk neuroblastoma is poor despite the availability of multimodal treatment. Here the authors show that high-risk neuroblastoma is sensitive to indisulam, a selective degrader of the splicing factor RBM39 through the dual targeting of RNA splicing and metabolism.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-022-28907-3
URL الوصول:	https://doaj.org/article/c91ed6203d624310b8e94805ee7888bd
رقم الأكسشن:	edsdoj.91ed6203d624310b8e94805ee7888bd
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-022-28907-3