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Clinical Efficacy and Safety of Human Mesenchymal Stem Cell Therapy for Degenerative Disc Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

التفاصيل البيبلوغرافية
العنوان: Clinical Efficacy and Safety of Human Mesenchymal Stem Cell Therapy for Degenerative Disc Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
المؤلفون: Baocheng Xie, Shichun Chen, Yongxiang Xu, Weichao Han, Runkai Hu, Minyi Chen, Ruirong He, Shaobo Ding
المصدر: Stem Cells International, Vol 2021 (2021)
بيانات النشر: Wiley, 2021.
سنة النشر: 2021
المجموعة: LCC:Internal medicine
مصطلحات موضوعية: Internal medicine, RC31-1245
الوصف: Degenerative disc disease (DDD) can cause severe low back pain, which will have a serious negative impact on the ability to perform daily tasks or activities. For the past few years, mesenchymal stem cell (MSC) transplantation has emerged as a promising strategy for the treatment of DDD. However, the clinical efficacy of MSC in the treatment of DDD still lacks clinical evidence and is controversial. We conducted a meta-analysis with randomized controlled trials (RCTs) to evaluate the clinical efficacy and safety of MSC transplantation in patients with DDD. We searched major databases using terms from the database’s inception through March 2021. The Cochrane bias risk assessment tool was used to assess quality. The analysis showed that MSC therapy could decrease visual analog scale (VAS) scores (SMD=−0.50, 95%CI=−0.68~−0.33, P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1687-966X
1687-9678
Relation: https://doaj.org/toc/1687-966X; https://doaj.org/toc/1687-9678
DOI: 10.1155/2021/9149315
URL الوصول: https://doaj.org/article/e91f28653d574303aa8af74760364e92
رقم الأكسشن: edsdoj.91f28653d574303aa8af74760364e92
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:1687966X
16879678
DOI:10.1155/2021/9149315