دورية أكاديمية
Clinical Efficacy and Safety of Human Mesenchymal Stem Cell Therapy for Degenerative Disc Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
العنوان: | Clinical Efficacy and Safety of Human Mesenchymal Stem Cell Therapy for Degenerative Disc Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
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المؤلفون: | Baocheng Xie, Shichun Chen, Yongxiang Xu, Weichao Han, Runkai Hu, Minyi Chen, Ruirong He, Shaobo Ding |
المصدر: | Stem Cells International, Vol 2021 (2021) |
بيانات النشر: | Wiley, 2021. |
سنة النشر: | 2021 |
المجموعة: | LCC:Internal medicine |
مصطلحات موضوعية: | Internal medicine, RC31-1245 |
الوصف: | Degenerative disc disease (DDD) can cause severe low back pain, which will have a serious negative impact on the ability to perform daily tasks or activities. For the past few years, mesenchymal stem cell (MSC) transplantation has emerged as a promising strategy for the treatment of DDD. However, the clinical efficacy of MSC in the treatment of DDD still lacks clinical evidence and is controversial. We conducted a meta-analysis with randomized controlled trials (RCTs) to evaluate the clinical efficacy and safety of MSC transplantation in patients with DDD. We searched major databases using terms from the database’s inception through March 2021. The Cochrane bias risk assessment tool was used to assess quality. The analysis showed that MSC therapy could decrease visual analog scale (VAS) scores (SMD=−0.50, 95%CI=−0.68~−0.33, P |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1687-966X 1687-9678 |
Relation: | https://doaj.org/toc/1687-966X; https://doaj.org/toc/1687-9678 |
DOI: | 10.1155/2021/9149315 |
URL الوصول: | https://doaj.org/article/e91f28653d574303aa8af74760364e92 |
رقم الأكسشن: | edsdoj.91f28653d574303aa8af74760364e92 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 1687966X 16879678 |
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DOI: | 10.1155/2021/9149315 |