دورية أكاديمية
Safety and Efficacy of the Metabolic Profiling of the BIMRT Utilizing 18F FDG PET-CT
| العنوان: | Safety and Efficacy of the Metabolic Profiling of the BIMRT Utilizing 18F FDG PET-CT |
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| المؤلفون: | Ya-Zheng Dang MD, Dong-Xian Zhang MS, Guo-Dong Wang MS, Hong-Liang Zhao MS, Shi-Gao Huang PhD, Jie Li BS |
| المصدر: | Technology in Cancer Research & Treatment, Vol 19 (2020) |
| بيانات النشر: | SAGE Publishing, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Aim: This study aims to evaluate the safety and efficacy of fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG-PET/CT) guided intensity-modulated radiation therapy (IMRT) for patients with peritoneal metastases. Patients and Methods: A total of 55 patients with peritoneal metastases were treated with 18F-FDG-PET/CT-guided IMRT (BIMRT) from January 2012 to January 2019. They were prescribed with a fraction of the median dose of 2 Gy to a total dose of 50.4 Gy. The multivariate analysis was used the Cox proportional hazard model and the Kaplan-Meier plot was used to perform local control rate (LCR), progression-free survival (PFS), and overall survival (OS) analysis. Results: The 1-year, 2-year, and 3-year LCR were 72.7%, 36.4%, and 9.1%, respectively; the 1-year, 2-year, and 3-year PFS were 69.1%, 30.9%, and 7.3%, respectively, and the median PFS time was 18 months. The 1-year, 3-year and 5-year OS were 70.9%, 28.7%, and 4.2%, respectively. Based on the multivariate analysis using the Cox proportional hazard model, the Karnofsky performance status (KPS) score and radiotherapy joint chemotherapy (RJC) method were independent prognostic-related indicators (P < 0.0001). Conclusion: BIMRT may be a safe and effective treatment for patients with peritoneal metastases, especially for patients who cannot undergo surgery. In addition, the results indicated that the patient’s KPS score and RJC method were independent prognostic-related indicators for patients survival time. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1533-0338 15330338 |
| Relation: | https://doaj.org/toc/1533-0338 |
| DOI: | 10.1177/1533033820960723 |
| URL الوصول: | https://doaj.org/article/91f3369d45c347b994f200d861f3e948 |
| رقم الأكسشن: | edsdoj.91f3369d45c347b994f200d861f3e948 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15330338 |
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| DOI: | 10.1177/1533033820960723 |