دورية أكاديمية
Characterization of the cagA-gene in Helicobacter pylori in Mongolia and detection of two EPIYA-A enriched CagA types
| العنوان: | Characterization of the cagA-gene in Helicobacter pylori in Mongolia and detection of two EPIYA-A enriched CagA types |
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| المؤلفون: | Oyunbaatar Altanbayar, Avarzed Amgalanbaatar, Chimeddorj Battogtokh, Narmandakh Bayarjargal, Dana Belick, Malte Kohns Vasconcelos, Colin R. Mackenzie, Klaus Pfeffer, Birgit Henrich |
| المصدر: | International Journal of Medical Microbiology, Vol 312, Iss 3, Pp 151552- (2022) |
| بيانات النشر: | Elsevier, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Microbiology LCC:Other systems of medicine |
| مصطلحات موضوعية: | Helicobacter pylori, CagA protein, EPIYA polymorphisms, Western type, Mongolian H. pylori strains, Microbiology, QR1-502, Other systems of medicine, RZ201-999 |
| الوصف: | Helicobacter pylori infection is strongly associated with gastritis, gastroduodenal ulcer disease and gastric carcinoma. The virulence of H. pylori strains increases with the presence of the pathogenicity island PAI, which encodes a Type 4 Secretion System and the oncoprotein CagA. Two major CagA types can be distinguished by differences in the repetitive EPIYA region in the C-terminal sequence; the more virulent East Asian CagA type with EPIYA-A, -B, and -D motifs and the Western CagA type with EPIYA-A, -B, and C motifs, the virulence of which is associated with the multitude of EPIYA-C motifs.In this study, the cagA gene was characterized in H. pylori strains isolated from Mongolians suffering from gastritis (80%) or ulcer (20%). The EPIYA region of 53 isolates was determined by PCR-amplification of overlapping cagA regions and subsequent Sanger sequencing. Only one H. pylori isolate carried the East Asian type (ABD) and 52 isolates the Western type of CagA, thereof 30 the EPIYA type ABC, 19 the ABCC type and one each of type ABCCCC, AAABC and AAAAB. An amino acid exchange from EPIYA-B to EPIYT-B was predominantly found in CagA proteins in strains with |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1438-4221 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1438422122000054; https://doaj.org/toc/1438-4221 |
| DOI: | 10.1016/j.ijmm.2022.151552 |
| URL الوصول: | https://doaj.org/article/92353427bf76405ea869ca71d04cd74f |
| رقم الأكسشن: | edsdoj.92353427bf76405ea869ca71d04cd74f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 14384221 |
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| DOI: | 10.1016/j.ijmm.2022.151552 |