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Causal effect of the age at first birth with depression: a mendelian randomization study

التفاصيل البيبلوغرافية
العنوان: Causal effect of the age at first birth with depression: a mendelian randomization study
المؤلفون: Wanshu Guo, Yuanyuan Guo, Shaokang Song, Xuankai Huang, Yu Zhang, Aizhen Zhang, Fangrong Meng, Minghang Chang, Zhipeng Wang
المصدر: BMC Medical Genomics, Vol 17, Iss 1, Pp 1-8 (2024)
بيانات النشر: BMC, 2024.
سنة النشر: 2024
المجموعة: LCC:Internal medicine
LCC:Genetics
مصطلحات موضوعية: Casual effect, Age at first birth, Depression, Mendelian randomization, Major depressive disorder, Postpartum depression, Internal medicine, RC31-1245, Genetics, QH426-470
الوصف: Abstract Background This study aimed to explore the causal relationship between age at first birth (AFB) and depression. Methods Using the univariable Mendelian randomization (UVMR) and multivariable Mendelian randomization (MVMR) methods to examine the potential correlation between age at first birth (AFB) and major depressive disorder and postpartum depression. A public database was used to obtain the genome-wide association studies (GWAS) summary data. We put inverse-variance-weighted (IVW) as the primary method in Mendelian randomization (MR) analysis and used sensitivity analysis to confirm the robustness of our result. Results We found a significant causal association between AFB and major depressive disorder by using the IVW algorithm (odd ratio [OR] 0.826; 95% confidence interval [CI] 0.793 − 0.861; P = 4.51 × 10− 20). MR-Egger, weighted median, simple mode and weighted mode method concluded the same result (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1755-8794
Relation: https://doaj.org/toc/1755-8794
DOI: 10.1186/s12920-024-01966-9
URL الوصول: https://doaj.org/article/92e1bdd354a1414ca149d9b63659d109
رقم الأكسشن: edsdoj.92e1bdd354a1414ca149d9b63659d109
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17558794
DOI:10.1186/s12920-024-01966-9