دورية أكاديمية
Causal effect of the age at first birth with depression: a mendelian randomization study
العنوان: | Causal effect of the age at first birth with depression: a mendelian randomization study |
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المؤلفون: | Wanshu Guo, Yuanyuan Guo, Shaokang Song, Xuankai Huang, Yu Zhang, Aizhen Zhang, Fangrong Meng, Minghang Chang, Zhipeng Wang |
المصدر: | BMC Medical Genomics, Vol 17, Iss 1, Pp 1-8 (2024) |
بيانات النشر: | BMC, 2024. |
سنة النشر: | 2024 |
المجموعة: | LCC:Internal medicine LCC:Genetics |
مصطلحات موضوعية: | Casual effect, Age at first birth, Depression, Mendelian randomization, Major depressive disorder, Postpartum depression, Internal medicine, RC31-1245, Genetics, QH426-470 |
الوصف: | Abstract Background This study aimed to explore the causal relationship between age at first birth (AFB) and depression. Methods Using the univariable Mendelian randomization (UVMR) and multivariable Mendelian randomization (MVMR) methods to examine the potential correlation between age at first birth (AFB) and major depressive disorder and postpartum depression. A public database was used to obtain the genome-wide association studies (GWAS) summary data. We put inverse-variance-weighted (IVW) as the primary method in Mendelian randomization (MR) analysis and used sensitivity analysis to confirm the robustness of our result. Results We found a significant causal association between AFB and major depressive disorder by using the IVW algorithm (odd ratio [OR] 0.826; 95% confidence interval [CI] 0.793 − 0.861; P = 4.51 × 10− 20). MR-Egger, weighted median, simple mode and weighted mode method concluded the same result (P |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1755-8794 |
Relation: | https://doaj.org/toc/1755-8794 |
DOI: | 10.1186/s12920-024-01966-9 |
URL الوصول: | https://doaj.org/article/92e1bdd354a1414ca149d9b63659d109 |
رقم الأكسشن: | edsdoj.92e1bdd354a1414ca149d9b63659d109 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 17558794 |
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DOI: | 10.1186/s12920-024-01966-9 |