دورية أكاديمية
Exploring the Genetic Diversity of Epstein–Barr Virus among Patients with Gastric Cancer in Southern Chile
| العنوان: | Exploring the Genetic Diversity of Epstein–Barr Virus among Patients with Gastric Cancer in Southern Chile |
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| المؤلفون: | María Elena Reyes, Louise Zanella, Ismael Riquelme, Kurt Buchegger, Bárbara Mora-Lagos, Pablo Guzmán, Patricia García, Juan C. Roa, Carmen Gloria Ili, Priscilla Brebi |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 14, p 11276 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | gastric cancer, Epstein–Barr virus (EBV), EBNA3A, phylogeny, Chile, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The Epstein–Barr virus (EBV) has been associated with gastric cancer (GC), one of the deadliest malignancies in Chile and the world. Little is known about Chilean EBV strains. This study aims to investigate the frequency and genetic diversity of EBV in GC in patients in southern Chile. To evaluate the prevalence of EBV in GC patients from the Chilean population, we studied 54 GC samples using the gold standard detection method of EBV-encoded small RNA (EBER). The EBV-positive samples were subjected to amplification and sequencing of the Epstein–Barr virus nuclear protein 3A (EBNA3A) gene to evaluate the genetic diversity of EBV strains circulating in southern Chile. In total, 22.2% of the GC samples were EBV-positive and significantly associated with diffuse-type histology (p = 0.003). Phylogenetic analyses identified EBV-1 and EBV-2 in the GC samples, showing genetic diversity among Chilean isolates. This work provides important information for an epidemiological follow-up of the different EBV subtypes that may cause GC in southern Chile. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 24141127 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/24/14/11276; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms241411276 |
| URL الوصول: | https://doaj.org/article/c931505592dd4e9f9bd3f61bbd655d9a |
| رقم الأكسشن: | edsdoj.931505592dd4e9f9bd3f61bbd655d9a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24141127 14220067 16616596 |
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| DOI: | 10.3390/ijms241411276 |