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Histological regional analysis of the aortic root and thoracic ascending aorta: a complete analysis of aneurysms from root to arch

التفاصيل البيبلوغرافية
العنوان: Histological regional analysis of the aortic root and thoracic ascending aorta: a complete analysis of aneurysms from root to arch
المؤلفون: Timothy Luke Surman, John Matthew Abrahams, Jim Manavis, John Finnie, Dermot O’Rourke, Karen Jane Reynolds, James Edwards, Michael George Worthington, John Beltrame
المصدر: Journal of Cardiothoracic Surgery, Vol 16, Iss 1, Pp 1-10 (2021)
بيانات النشر: BMC, 2021.
سنة النشر: 2021
المجموعة: LCC:Surgery
LCC:Anesthesiology
مصطلحات موضوعية: Aortic root, Ascending aorta, Aneurysms, Histology, Immunohistochemistry, Surgery, RD1-811, Anesthesiology, RD78.3-87.3
الوصف: Abstract Background Although aortic root and ascending aortic aneurysms are treated the same, they differ in embryological development and pathological processes. This study examines the microscopic structural differences between aortic root and ascending aortic aneurysms, correlating these features to the macroscopic pathophysiological processes. Methods We obtained surgical samples from ascending aortic aneurysms (n = 11), aortic root aneurysms (n = 3), and non-aneurysmal patients (n = 7), Aortic collagen and elastin content were examined via histological analysis, and immunohistochemistry techniques used to determine collagen I, III, and IV subtypes. Analysis was via observational features, and colour deconvolution quantification techniques. Results Elastin fiber disruption and fragmentation was the most extensive in the proximal aneurysmal regions. Medial fibrosis and collagen density increased in proximal aneurysmal regions and aortic root aneurysms (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1749-8090
Relation: https://doaj.org/toc/1749-8090
DOI: 10.1186/s13019-021-01641-5
URL الوصول: https://doaj.org/article/931c09c683a54ddd9078c2e173009ffc
رقم الأكسشن: edsdoj.931c09c683a54ddd9078c2e173009ffc
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17498090
DOI:10.1186/s13019-021-01641-5