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Suppressing Chondrocyte Hypertrophy to Build Better Cartilage

التفاصيل البيبلوغرافية
العنوان: Suppressing Chondrocyte Hypertrophy to Build Better Cartilage
المؤلفون: Christian Shigley, Jay Trivedi, Ozair Meghani, Brett D. Owens, Chathuraka T. Jayasuriya
المصدر: Bioengineering, Vol 10, Iss 6, p 741 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Technology
LCC:Biology (General)
مصطلحات موضوعية: chondrocyte hypertrophy, cartilage restoration, cartilage repair, osteoarthritis, Technology, Biology (General), QH301-705.5
الوصف: Current clinical strategies for restoring cartilage defects do not adequately consider taking the necessary steps to prevent the formation of hypertrophic tissue at injury sites. Chondrocyte hypertrophy inevitably causes both macroscopic and microscopic level changes in cartilage, resulting in adverse long-term outcomes following attempted restoration. Repairing/restoring articular cartilage while minimizing the risk of hypertrophic neo tissue formation represents an unmet clinical challenge. Previous investigations have extensively identified and characterized the biological mechanisms that regulate cartilage hypertrophy with preclinical studies now beginning to leverage this knowledge to help build better cartilage. In this comprehensive article, we will provide a summary of these biological mechanisms and systematically review the most cutting-edge strategies for circumventing this pathological hallmark of osteoarthritis.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2306-5354
Relation: https://www.mdpi.com/2306-5354/10/6/741; https://doaj.org/toc/2306-5354
DOI: 10.3390/bioengineering10060741
URL الوصول: https://doaj.org/article/cd934c730d5149c9b323754ab7f3b8fc
رقم الأكسشن: edsdoj.934c730d5149c9b323754ab7f3b8fc
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23065354
DOI:10.3390/bioengineering10060741