دورية أكاديمية
Trafficked Proteins—Druggable in Plasmodium falciparum?
| العنوان: | Trafficked Proteins—Druggable in Plasmodium falciparum? |
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| المؤلفون: | Jasmin Lindner, Kamila Anna Meissner, Isolmar Schettert, Carsten Wrenger |
| المصدر: | International Journal of Cell Biology, Vol 2013 (2013) |
| بيانات النشر: | Wiley, 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Cytology |
| مصطلحات موضوعية: | Cytology, QH573-671 |
| الوصف: | Malaria is an infectious disease that results in serious health problems in the countries in which it is endemic. Annually this parasitic disease leads to more than half a million deaths; most of these are children in Africa. An effective vaccine is not available, and the treatment of the disease is solely dependent on chemotherapy. However, drug resistance is spreading, and the identification of new drug targets as well as the development of new antimalarials is urgently required. Attention has been drawn to a variety of essential plasmodial proteins, which are targeted to intra- or extracellular destinations, such as the digestive vacuole, the apicoplast, or into the host cell. Interfering with the action or the transport of these proteins will impede proliferation of the parasite. In this mini review, we will shed light on the present discovery of chemotherapeutics and potential drug targets involved in protein trafficking processes in the malaria parasite. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1687-8876 1687-8884 |
| Relation: | https://doaj.org/toc/1687-8876; https://doaj.org/toc/1687-8884 |
| DOI: | 10.1155/2013/435981 |
| URL الوصول: | https://doaj.org/article/93893b845d8841dfbe8fd339cc49c872 |
| رقم الأكسشن: | edsdoj.93893b845d8841dfbe8fd339cc49c872 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16878876 16878884 |
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| DOI: | 10.1155/2013/435981 |