دورية أكاديمية
Histopathological and clinical analysis of COVID-19-infected placentas
| العنوان: | Histopathological and clinical analysis of COVID-19-infected placentas |
|---|---|
| المؤلفون: | Aline C. M. Nascimento, Elyzabeth Avvad-Portari, Marcelo Meuser-Batista, Thayana Camara Conde, Renato Augusto Moreira de Sá, Natalia Salomao, Kissila Rabelo, Erica Stein Ciasca, Michelle de Oliveira Brendolin, Zilton Vasconcelos, Patricia Brasil, Maria Elisabeth Moreira |
| المصدر: | Surgical and Experimental Pathology, Vol 7, Iss 1, Pp 1-9 (2024) |
| بيانات النشر: | BMC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Surgery LCC:Pathology |
| مصطلحات موضوعية: | Placenta, COVID-19, SARS-CoV-2, Histopathology, Clinical outcome, Surgery, RD1-811, Pathology, RB1-214 |
| الوصف: | Abstract Background The impact of COVID-19 pandemic in pregnant patients is an important emerging topic. Evidence of transplacental transmission and typical histopathological alterations in the placenta are controversial in the literature. Methods This was a prospective observational cohort multicenter study in which we selected 23 placentas of 21 patients that showed detection of SARS-CoV-2 RNA by RT-PCR in the placenta tissue and described both morphological and clinical characteristics. Immunohistochemistry was performed to localize the virus in the specimens. Results Most of the patients were asymptomatic (61.9%) and preterm delivery was observed in 8 patients (34.7%). In relation to histopathological features, all the placentas showed evidence of maternal vascular malperfusion, as well as some degree of villitis with a high frequency of high grade placentitis (73.9%) and chronic and/or acute intervillositis (82.6%). We observed immunopositivity for SARS-CoV-2 antibody in 69.5% of the cases, notably in the syncytiotrophoblast. Conclusions We reported histopathological features of placentas with viral detection in the tissue, thus providing evidence that SARS-CoV-2 can affect the placenta, although maternal and neonatal clinical outcome is usually mild. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2520-8454 |
| Relation: | https://doaj.org/toc/2520-8454 |
| DOI: | 10.1186/s42047-024-00146-4 |
| URL الوصول: | https://doaj.org/article/93b708659522484c8bd8737643c192d7 |
| رقم الأكسشن: | edsdoj.93b708659522484c8bd8737643c192d7 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 25208454 |
|---|---|
| DOI: | 10.1186/s42047-024-00146-4 |