دورية أكاديمية
Hsa_circRNA_0084043 promoting tumorigenesis in glioma through miR-577 sponging
| العنوان: | Hsa_circRNA_0084043 promoting tumorigenesis in glioma through miR-577 sponging |
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| المؤلفون: | Jin Qian, Chunyan Chen, Changping Zhao, Xing Xu, Yingna Xu, Yong Zhang, Chunfa Qian |
| المصدر: | Heliyon, Vol 9, Iss 9, Pp e19219- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Glioma, circRNA_0084043, miR-577, SNX5, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Circular RNAs (circRNAs) are important non-coding RNAs (ncRNAs) involved in the development of multiple human diseases, especially cancers. circRNA_0084043 is significantly involved in the progression of melanoma. However, whether circRNA_0084043 is associated with glioma remains unknown. In this study, the upregulation of circRNA_0084043 in glioma and the association between circRNA_0084043 and glioma grade were identified. Our results showed that circRNA_0084043 is significantly involved in the proliferative, migratory, and invasive capacities of glioma cells. The results obtained from starBase, luciferase reporter assays, RNA immunoprecipitation assays, and RNA pull-down assays demonstrated that circRNA_0084043 acts as a direct sponge for miR-577. TargetScan algorithm was used to identify potential miR-577 targets, it was found that sorting nexin 5 (SNX5) is a candidate bound to miR-577. Finally, cell experiments testified that circRNA_0084043 enhanced growth, migration and invasion of glioma through the regulation of miR-577-mediated SNX5. Taken together, we concluded that circRNA_0084043 in the miR-577/SNX5 axis can be used as a candidate target for glioma therapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844023064277; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2023.e19219 |
| URL الوصول: | https://doaj.org/article/e940ebb00cdc4a18b36cfe3b17db37d2 |
| رقم الأكسشن: | edsdoj.940ebb00cdc4a18b36cfe3b17db37d2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2023.e19219 |