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Artificial switches induce the bespoke production of functional compounds in marine microalgae Chlorella by neutralizing CO2

التفاصيل البيبلوغرافية
العنوان: Artificial switches induce the bespoke production of functional compounds in marine microalgae Chlorella by neutralizing CO2
المؤلفون: Jiahua Gu, Yuan Xiao, Mingcan Wu, Aoqi Wang, Xinyu Cui, Yi Xin, Kalyanee Paithoonrangsarid, Yandu Lu
المصدر: Biotechnology for Biofuels and Bioproducts, Vol 16, Iss 1, Pp 1-14 (2023)
بيانات النشر: BMC, 2023.
سنة النشر: 2023
المجموعة: LCC:Biotechnology
LCC:Fuel
مصطلحات موضوعية: Chlorella, CO2 tolerance, Microalgae, Multiomics, Mutant library, Lipids, Biotechnology, TP248.13-248.65, Fuel, TP315-360
الوصف: Abstract To improve the CO2 tolerance of a marine microalga Chlorella sp. of which the production capacity has been demonstrated industrially, a mutant library was created and a strain hct53 was screened. Compared to the parental strain, hct53 shows a high CO2 capture capacity, while starch biosynthesis is compromised, with increases in health beneficial metabolites and antioxidant capacity. Global gene expression and genome-wide mutation distribution revealed that transcript choreography was concomitant with more active CO2 sequestration, an increase in the lipid synthesis, and a decrease in the starch and protein synthesis. These results suggest that artificial trait improvement via mutagenesis, couple with multiomics analysis, helps discover genetic switches that induce the bespoke conversion of carbon flow from “redundant metabolites” to valuable ones for functional food.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2731-3654
Relation: https://doaj.org/toc/2731-3654
DOI: 10.1186/s13068-023-02381-5
URL الوصول: https://doaj.org/article/9433024eccee443b8131c9d15dcab51d
رقم الأكسشن: edsdoj.9433024eccee443b8131c9d15dcab51d
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:27313654
DOI:10.1186/s13068-023-02381-5