دورية أكاديمية
hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma
العنوان: | hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma |
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المؤلفون: | Pauline Herviou, Morgane Le Bras, Leïla Dumas, Corinne Hieblot, Julia Gilhodes, Gianluca Cioci, Jean-Philippe Hugnot, Alfred Ameadan, François Guillonneau, Erik Dassi, Anne Cammas, Stefania Millevoi |
المصدر: | Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020) |
بيانات النشر: | Nature Portfolio, 2020. |
سنة النشر: | 2020 |
المجموعة: | LCC:Science |
مصطلحات موضوعية: | Science |
الوصف: | RNA G-quadruplexes (RG4s) have been functionally linked to cancer gene expression. Here, Herviou, Le Bras et al. have identified the protein machinery modulating RG4s and reveal the role and mechanism of hnRNP H/F and DHX36 in RG4-mediated translational regulation affecting cancer treatment in glioblastoma. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2041-1723 |
Relation: | https://doaj.org/toc/2041-1723 |
DOI: | 10.1038/s41467-020-16168-x |
URL الوصول: | https://doaj.org/article/943f94a9317e43c69d93a0684d2b3375 |
رقم الأكسشن: | edsdoj.943f94a9317e43c69d93a0684d2b3375 |
قاعدة البيانات: | Directory of Open Access Journals |
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