دورية أكاديمية
Dissecting The role of Plasmodium metacaspase-2 in malaria gametogenesis and sporogony
| العنوان: | Dissecting The role of Plasmodium metacaspase-2 in malaria gametogenesis and sporogony |
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| المؤلفون: | Vandana Kumari, Kona Madhavinadha Prasad, Inderjeet Kalia, Gagandeep Sindhu, Rajnikant Dixit, Diwan S. Rawat, O. P. Singh, Agam P. Singh, Kailash C. Pandey |
| المصدر: | Emerging Microbes and Infections, Vol 11, Iss 1, Pp 938-955 (2022) |
| بيانات النشر: | Taylor & Francis Group, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Infectious and parasitic diseases LCC:Microbiology |
| مصطلحات موضوعية: | Malaria, metacaspase, specific inhibitor, Plasmodium transmission, sporogony, An. stephensi, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502 |
| الوصف: | The family of apicomplexan specific proteins contains caspases–like proteins called “metacaspases”. These enzymes are present in the malaria parasite but absent in human; therefore, these can be explored as potential drug targets. We deleted the MCA-2 gene from Plasmodium berghei genome using a gene knockout strategy to decipher its precise function. This study has identified that MCA-2 plays an important role in parasite transmission since it is critical for the formation of gametocytes and for maintaining an appropriate number of infectious sporozoites required for sporogony. It is noticeable that a significant reduction in gametocyte, oocysts, ookinete and sporozoites load along with a delay in hepatocytes invasion were observed in the MCA-2 knockout parasite. Furthermore, a study found the two MCA-2 inhibitory molecules known as C-532 and C-533, which remarkably inhibited the MCA-2 activity, abolished the in vitro parasite growth, and also impaired the transmission cycle of P. falciparum and P. berghei in An. stephensi. Our findings indicate that the deletion of MCA-2 hampers the Plasmodium development during erythrocytic and exo-erythrocytic stages, and its inhibition by C-532 and C-533 critically affects the malaria transmission biology. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 22221751 2222-1751 |
| Relation: | https://doaj.org/toc/2222-1751 |
| DOI: | 10.1080/22221751.2022.2052357 |
| URL الوصول: | https://doaj.org/article/c94491cc786948dab8772b14d7e46450 |
| رقم الأكسشن: | edsdoj.94491cc786948dab8772b14d7e46450 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 22221751 |
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| DOI: | 10.1080/22221751.2022.2052357 |