دورية أكاديمية

Influence of intraoperative vasopressor use on indocyanine green fluorescence angiography: first evaluation in an experimental model

التفاصيل البيبلوغرافية
العنوان: Influence of intraoperative vasopressor use on indocyanine green fluorescence angiography: first evaluation in an experimental model
المؤلفون: Mahdi Al-Taher, Tim Pruimboom, Rutger M. Schols, Nariaki Okamoto, Nicole D. Bouvy, Laurents P. S. Stassen, René R. W. J. van der Hulst, Michael Kugler, Alexandre Hostettler, Eric Noll, Jacques Marescaux, Sophie Diemunsch, Michele Diana
المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
بيانات النشر: Nature Portfolio, 2021.
سنة النشر: 2021
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Abstract Intraoperative indocyanine green (ICG) fluorescence angiography has gained popularity and acceptance in many surgical fields for the real-time assessment of tissue perfusion. Although vasopressors have the potential to preclude an accurate assessment of tissue perfusion, there is a lack of literature with regards to its effect on ICG fluorescence angiography. An experimental porcine model was used to expose the small bowel for quantitative tissue perfusion assessment. Three increasing doses of norepinephrine infusion (0.1, 0.5, and 1.0 µg/kg/min) were administered intravenously over a 25-min interval. Time-to-peak fluorescence intensity (TTP) was the primary outcome. Secondary outcomes included absolute fluorescence intensity and local capillary lactate (LCL) levels. Five large pigs (mean weight: 40.3 ± 4.24 kg) were included. There was no significant difference in mean TTP (in seconds) at baseline (4.23) as compared to the second (3.90), third (4.41), fourth (4.60), and fifth ICG assessment (5.99). As a result of ICG accumulation, the mean and the maximum absolute fluorescence intensity were significantly different as compared to the baseline assessment. There was no significant difference in LCL levels (in mmol/L) at baseline (0.74) as compared to the second (0.82), third (0.64), fourth (0.60), and fifth assessment (0.62). Increasing doses of norepinephrine infusion have no significant influence on bowel perfusion using ICG fluorescence angiography.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-021-89223-2
URL الوصول: https://doaj.org/article/e944fad2fb354d03afad5e64991e3fa6
رقم الأكسشن: edsdoj.944fad2fb354d03afad5e64991e3fa6
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-021-89223-2