دورية أكاديمية
Melatonin as an Oncostatic Molecule Based on Its Anti-Aromatase Role in Breast Cancer
| العنوان: | Melatonin as an Oncostatic Molecule Based on Its Anti-Aromatase Role in Breast Cancer |
|---|---|
| المؤلفون: | Yunho Jin, Yoo Jin Choi, Kyu Heo, Seong Joon Park |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 1, p 438 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | breast cancer, estrogen, aromatase, melatonin, oncostatic, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Breast cancer is the most common type of cancer. In the developmental stages of breast cancer, estrogens are strongly involved. As estrogen synthesis is regulated by the enzyme aromatase, targeting the activity of this enzyme represents a therapeutic option. The pineal hormone melatonin may exert a suppressive role on aromatase activity, leading to reduced estrogen biosynthesis. A melatonin-mediated decrease in the expression of aromatase promoters and associated genes would provide suitable evidence of this molecule’s efficacy as an aromatase inhibitor. Furthermore, melatonin intensifies radiation-induced anti-aromatase effects and counteracts the unwanted disadvantages of chemotherapeutic agents. In this manner, this review summarizes the inhibitory role of melatonin in aromatase action, suggesting its role as a possible oncostatic molecule in breast cancer. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/22/1/438; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms22010438 |
| URL الوصول: | https://doaj.org/article/946851b149d645d7949865bd5740faac |
| رقم الأكسشن: | edsdoj.946851b149d645d7949865bd5740faac |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
|---|---|
| DOI: | 10.3390/ijms22010438 |