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Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Lines

التفاصيل البيبلوغرافية
العنوان: Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Lines
المؤلفون: Alexander M. Demin, Alexander V. Vakhrushev, Alexandra G. Pershina, Marina S. Valova, Lina V. Efimova, Alexandra A. Syomchina, Mikhail A. Uimin, Artem S. Minin, Galina L. Levit, Victor P. Krasnov, Valery N. Charushin
المصدر: International Journal of Molecular Sciences, Vol 23, Iss 16, p 9093 (2022)
بيانات النشر: MDPI AG, 2022.
سنة النشر: 2022
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: magnetic nanoparticles, SiO2, PEG, doxorubicin, alternating magnetic field, tumor cells, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Novel nanocomposite materials based on Fe3O4 magnetic nanoparticles (MNPs) coated with silica and covalently modified by [(3-triethoxysilyl)propyl]succinic acid–polyethylene glycol (PEG 3000) conjugate, which provides a high level of doxorubicin (Dox) loading, were obtained. The efficiency of Dox desorption from the surface of nanomaterials under the action of an alternating magnetic field (AMF) in acidic and neutral media was evaluated. Their high cytotoxicity against tumor cells, as well as the drug release upon application of AMF, which leads to an increase in the cytotoxic effect, was demonstrated.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
1661-6596
Relation: https://www.mdpi.com/1422-0067/23/16/9093; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms23169093
URL الوصول: https://doaj.org/article/e9494c95f9124536aaad38e4f2e88f4d
رقم الأكسشن: edsdoj.9494c95f9124536aaad38e4f2e88f4d
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
16616596
DOI:10.3390/ijms23169093