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Diagnosis of atypical myopathy based on organic acid and acylcarnitine profiles and evolution of biomarkers in surviving horses

التفاصيل البيبلوغرافية
العنوان: Diagnosis of atypical myopathy based on organic acid and acylcarnitine profiles and evolution of biomarkers in surviving horses
المؤلفون: Déborah Mathis, Jörn Oliver Sass, Claudia Graubner, Angelika Schoster
المصدر: Molecular Genetics and Metabolism Reports, Vol 29, Iss , Pp 100827- (2021)
بيانات النشر: Elsevier, 2021.
سنة النشر: 2021
المجموعة: LCC:Medicine (General)
LCC:Biology (General)
مصطلحات موضوعية: Acquired multiple acyl-CoA dehydrogenase deficiency, Seasonal pasture myopathy, Hypoglycin A, Medicine (General), R5-920, Biology (General), QH301-705.5
الوصف: Background: Atypical myopathy (AM), an acquired multiple acyl-CoA dehydrogenase deficiency (MADD) in horses, induce changes in mitochondrial metabolism. Only few veterinary laboratories offer diagnostic testing for this disease. Inborn and acquired MADD exist in humans, therefore determination of organic acids (OA) in urine and acylcarnitines (AC) in blood by assays available in medical laboratories can serve as AM diagnostics. The evolution of OA and AC profiles in surviving horses is unreported. Methods: AC profiles using electrospray ionization tandem mass spectrometry (ESI-MS/MS) and OA in urine using gas chromatography mass spectrometry (GC–MS) were determined in dried blot spots (DBS, n = 7) and urine samples (n = 5) of horses with AM (n = 7) at disease presentation and in longitudinal samples from 3/4 survivors and compared to DBS (n = 16) and urine samples (n = 7) from control horses using the Wilcoxon test. Results: All short- (C2-C5) and medium-chain (C6-C12) AC in blood differed significantly (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2214-4269
Relation: http://www.sciencedirect.com/science/article/pii/S2214426921001221; https://doaj.org/toc/2214-4269
DOI: 10.1016/j.ymgmr.2021.100827
URL الوصول: https://doaj.org/article/94ed41f643b04f99b3a8537fa780aea2
رقم الأكسشن: edsdoj.94ed41f643b04f99b3a8537fa780aea2
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:22144269
DOI:10.1016/j.ymgmr.2021.100827