دورية أكاديمية
Synthesis of Streptococcus pneumoniae serotype 9V oligosaccharide antigens
| العنوان: | Synthesis of Streptococcus pneumoniae serotype 9V oligosaccharide antigens |
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| المؤلفون: | Sharavathi G. Parameswarappa, Claney L. Pereira, Peter H. Seeberger |
| المصدر: | Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 1693-1699 (2020) |
| بيانات النشر: | Beilstein-Institut, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Science LCC:Organic chemistry |
| مصطلحات موضوعية: | antigen, carbohydrate chemistry, oligosaccharide, streptococcus pneumoniae, vaccines, Science, Organic chemistry, QD241-441 |
| الوصف: | Streptococcus pneumoniae (SP) bacteria cause serious invasive diseases. SP bacteria are covered by a capsular polysaccharide (CPS) that is a virulence factor and the basis for SP polysaccharide and glycoconjugate vaccines. The serotype 9V is part of the currently marketed conjugate vaccine and contains an acetate modification. To better understand the importance of glycan modifications in general and acetylation in particular, defined oligosaccharide antigens are needed for serological and immunological studies. Here, we demonstrate a convergent [2 + 3] synthetic strategy to prepare the pentasaccharide repeating unit of 9V with and without an acetate group at the C-6 position of mannosamine. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1860-5397 |
| Relation: | https://doaj.org/toc/1860-5397 |
| DOI: | 10.3762/bjoc.16.140 |
| URL الوصول: | https://doaj.org/article/95c2ac40e5b74f84a49864facb7b42de |
| رقم الأكسشن: | edsdoj.95c2ac40e5b74f84a49864facb7b42de |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18605397 |
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| DOI: | 10.3762/bjoc.16.140 |