دورية أكاديمية
Safety monitoring of cytostatic handling
| العنوان: | Safety monitoring of cytostatic handling |
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| المؤلفون: | Hilda M. Rodríguez Montero, Elizabeth Reyes Reyes, Tania M. Escalante Leyva, Raidel Correa Aguila, Antonio Torres Valle, Elizabeth B. Cuétara-Lug |
| المصدر: | Journal of Pharmacy & Pharmacognosy Research, Vol 6, Iss 6, Pp 433-447 (2018) |
| بيانات النشر: | GarVal Editorial Ltda., 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Therapeutics. Pharmacology LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | cytostatic handling, Micronucleus test, occupational health, Therapeutics. Pharmacology, RM1-950, Pharmacy and materia medica, RS1-441 |
| الوصف: | Context: The Institute of Oncology and Radiobiology (INOR) is the leading institution for the diagnosis, treatment and follow up of cancer in Cuba. Cancer treatment is mainly by three methods: surgery, radiotherapy and chemotherapy. Pharmacological treatments involve the use of dangerous substances such as cytostatics, the handling of which threat the health of the occupationally exposed staff. Aims: To evaluate a biomarker of genotoxicity indicative of DNA damage in the biomonitoring of occupational risks associated with the administration of antineoplastic drugs to hospitalized patients. Methods: The determination of the frequency of micronuclei, in cells of the exfoliated oral mucosa was determined (Micronucleus test) in subjects who administer cytostatic drugs at the institute and a control group formed by administrative personal. Results: Present results evidenced that all exposed subjects possess the same DNA damage that non-exposed-ones. Such results are in concordance with the proper use of primary protection barriers and the adhesion to normalized operational procedures. Conclusions: The frequency of micronuclei is a useful biomarker for assessing DNA damage associated with the administration of antineoplastic drugs. The risk perception analysis (RISKPERCEP) in occupationally exposed subjects complements the occupational safety monitoring. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Spanish; Castilian |
| تدمد: | 0719-4250 |
| Relation: | http://jppres.com/jppres/pdf/vol6/jppres18.392_6.6.433.pdf; https://doaj.org/toc/0719-4250 |
| URL الوصول: | https://doaj.org/article/95f497e2169b4f99aed71d29fcdcb290 |
| رقم الأكسشن: | edsdoj.95f497e2169b4f99aed71d29fcdcb290 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 07194250 |
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