دورية أكاديمية
Multi-Omics Characteristics of Ferroptosis Associated with Colon Adenocarcinoma Typing and Survival
| العنوان: | Multi-Omics Characteristics of Ferroptosis Associated with Colon Adenocarcinoma Typing and Survival |
|---|---|
| المؤلفون: | Xiao-Qiong Chen, Ke Lian, Zi-Wei Chen, Xuan Zhang, Ting Li, Tao Wu, Tao Shen, Xin-Yi Cai, Xian-Shuo Cheng, Fu-Hui Xiao, Yun-Feng Li |
| المصدر: | Frontiers in Bioscience-Landmark, Vol 29, Iss 1, p 13 (2024) |
| بيانات النشر: | IMR Press, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biochemistry LCC:Biology (General) |
| مصطلحات موضوعية: | colon adenocarcinoma, ferroptosis, multi-omics, oncology, diagnostic signature, Biochemistry, QD415-436, Biology (General), QH301-705.5 |
| الوصف: | Background: Ferroptosis, an iron-dependent form of cell death, plays a crucial role in the progression of various cancers, including colon adenocarcinoma (COAD). However, the multi-omics signatures relevant to ferroptosis regulation in COAD diagnosis remain to be elucidated. Methods: The transcriptomic, miRNAomic, and methylomic profiles of COAD patients were acquired from the Cancer Genome Atlas (TCGA). Ferroptosis activity in these patients was determined, represented by a ferroptosis score (FS), using single-sample gene set enrichment analysis (ssGSEA) based on the expression of ferroptosis-related genes. Results: Results showed that the COAD patients with high-FS displayed favorable survival outcomes and heightened drug sensitivity. They also exhibited an up-regulation of genes involved in immune-related pathways (e.g., tumor necrosis factor signaling pathway), suggesting a correlation between immunity and ferroptosis in COAD progression. Furthermore, three survival prediction models were established based on 10 CpGs, 12 long non-coding RNAs (lncRNAs), and 14 microRNAs (miRNAs), respectively. These models demonstrated high accuracy in predicting COAD survival, achieving areas under the curve (AUC) >0.7. The variables used in the three models also showed strong correlations at different omics levels and were effective at discriminating between high-FS and low-FS COAD patients (AUC >0.7). Conclusions: This study identified different DNA methylation (DNAm), lncRNA, and miRNA characteristics between COAD patients with high and low ferroptosis activity. Furthermore, ferroptosis-related multi-omics signatures were established for COAD prognosis and classification. These insights present new opportunities for improving the efficacy of COAD therapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2768-6701 |
| Relation: | https://www.imrpress.com/journal/FBL/29/1/10.31083/j.fbl2901013; https://doaj.org/toc/2768-6701 |
| DOI: | 10.31083/j.fbl2901013 |
| URL الوصول: | https://doaj.org/article/9605e55e597e44168cf84a252b728f4b |
| رقم الأكسشن: | edsdoj.9605e55e597e44168cf84a252b728f4b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 27686701 |
|---|---|
| DOI: | 10.31083/j.fbl2901013 |