دورية أكاديمية
Developmental programming of skeletal muscle phenotype/metabolism
| العنوان: | Developmental programming of skeletal muscle phenotype/metabolism |
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| المؤلفون: | T.C.W. Markham, R.M. Latorre, P.G. Lawlor, C.J. Ashton, L.B. McNamara, R. Natter, A. Rowlerson, N.C. Stickland |
| المصدر: | Animal, Vol 3, Iss 7, Pp 1001-1012 (2009) |
| بيانات النشر: | Elsevier, 2009. |
| سنة النشر: | 2009 |
| المجموعة: | LCC:Animal culture |
| مصطلحات موضوعية: | muscle, fibre types, nutrition, gestation, pig, Animal culture, SF1-1100 |
| الوصف: | Skeletal muscle is a highly dynamic and malleable tissue that is able to adapt to different stimuli placed upon it, both during gestation and after birth, ultimately resulting in anatomical changes to muscle fibre composition. Variation in nutrient supply throughout gestation is common, whether in livestock or in the human. The specific effects of maternal nutrition on foetal development are at the forefront of scientific research. However, results describing how different maternal feeding strategies affect skeletal muscle fibre development in the offspring are not fully consistent, even where the same time windows during gestation have been examined. The aim of this study is to determine the effects of increased maternal nutrition (above the recommended levels) on the Musculus semitendinosus phenotype of progeny. In all, 24 pregnant sows were assigned to one of four feeding regimes during gestation; T1 (control group): 30 MJ digestible energy per day (MJ DE/day) throughout gestation, T2: same as that for T1 but increased to 60 MJ DE/day from 25 to 50 days of gestation (dg), T3: same as that for T1 but increased to 60 MJ DE/day from 50 to 80 dg, T4: same as that for T1 but increased nutrition to 60 MJ DE/day from 25 to 80 dg. Light- and heavy-weight littermate pairs of the same sex were selected at birth and individually fed to slaughter (c. 158 days). Histochemical and immunohistochemical staining were used to identify the predominantly oxidative (deep) and less oxidative (superficial) regions of the M. semitendinosus, and to determine total fibre number and proportions of fibre types. The results demonstrate that increased maternal nutrition alters skeletal muscle phenotype in the offspring by changing fibre-type proportions, leading to an increased oxidative capacity due to an increase in Type IIA fibres. No change in total muscle area, total muscle fibre number, or fibre cross-sectional area is observed. The precise molecular mechanism(s) by which these findings occur is being investigated. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1751-7311 17517311 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1751731109004637; https://doaj.org/toc/1751-7311 |
| DOI: | 10.1017/S1751731109004637 |
| URL الوصول: | https://doaj.org/article/96235d450d3741668f662d5906224576 |
| رقم الأكسشن: | edsdoj.96235d450d3741668f662d5906224576 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17517311 |
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| DOI: | 10.1017/S1751731109004637 |