دورية أكاديمية
أعرض في EDS

Intratumoral, rather than stromal, CD8+ T cells could be a potential negative prognostic marker in invasive breast cancer patients

التفاصيل البيبلوغرافية
العنوان: Intratumoral, rather than stromal, CD8+ T cells could be a potential negative prognostic marker in invasive breast cancer patients
المؤلفون: Ivana Catacchio, Nicola Silvestris, Emanuela Scarpi, Laura Schirosi, Anna Scattone, Anita Mangia
المصدر: Translational Oncology, Vol 12, Iss 3, Pp 585-595 (2019)
بيانات النشر: Elsevier, 2019.
سنة النشر: 2019
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: BACKGROUND: Tumor infiltrating lymphocytes (TILs) are widely considered a key sign of the immune interaction between host and tumor, and potentially prognostic biomarkers of good or bad outcome in many cancers, included invasive breast cancer (BC). However, results about the association between TIL typology, location and BC prognosis, are controversial. The aim of the study was to evaluated the prognostic significance of TIL subtypes (CD4+, CD8+, FOXP3+ T cells) and their location (stromal “s” and intratumoral “i” CD4+ and CD8+) in BC patients, focusing on the association between these markers and immunocheckpoint molecules such as cytotoxic T lymphocyte antigen 4 (CTLA-4), programmed cell death ligand 1 (PD-L1) and its receptor (PD-1). METHODS: CD4+, CD8+, FOXP3+, CTLA4+, PD-L1+ and PD-1+ expression was examined by immunohistochemistry on tissue microarrays (TMAs) from 180 BC patients. Univariate and Kaplan–Meier analyses of disease free survival (DFS) were performed to evaluate the prognostic significance of marker expression. RESULTS: Total CD8+ T cells were not significantly associated with DFS. Differently, patients with iCD8+ and sCD8+ overexpression showed a trend toward respectively a worse (P = .050) and a better 5-years DFS (P = .064). Interestingly, TIL expression of both PD-1+ and PD-L1+, was significantly associated with iCD8+ (P = .0004; P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1936-5233
48694908
Relation: http://www.sciencedirect.com/science/article/pii/S1936523318305461; https://doaj.org/toc/1936-5233
DOI: 10.1016/j.tranon.2018.12.005
URL الوصول: https://doaj.org/article/962a03fa48694908938d53fe602b220f
رقم الأكسشن: edsdoj.962a03fa48694908938d53fe602b220f
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19365233
48694908
DOI:10.1016/j.tranon.2018.12.005