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Supplementing exposure to hypoxia with a copper depleted diet does not exacerbate right ventricular remodeling in mice.

التفاصيل البيبلوغرافية
العنوان: Supplementing exposure to hypoxia with a copper depleted diet does not exacerbate right ventricular remodeling in mice.
المؤلفون: Ella M Poels, Nicole Bitsch, Jos M Slenter, M Eline Kooi, Chiel C de Theije, Leon J de Windt, Vanessa P M van Empel, Paula A da Costa Martins
المصدر: PLoS ONE, Vol 9, Iss 4, p e92983 (2014)
بيانات النشر: Public Library of Science (PLoS), 2014.
سنة النشر: 2014
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Pulmonary hypertension and subsequent right ventricular (RV) failure are associated with high morbidity and mortality. Prognosis is determined by occurrence of RV failure. Currently, adequate treatment for RV failure is lacking. Further research into the molecular basis for the development of RV failure as well as the development of better murine models of RV failure are therefore imperative. We hypothesize that adding a low-copper diet to chronic hypoxia in mice reinforces their individual effect and that the combination of mild pulmonary vascular remodeling and capillary rarefaction, induces RV failure.Six week old mice were subjected to normoxia (N; 21% O2) or hypoxia (H; 10% O2) during a period of 8 weeks and received either a normal diet (Cu+) or a copper depleted diet (Cu-). Cardiac function was assessed by echocardiography and MRI analysis.Here, we characterized a mouse model of chronic hypoxia combined with a copper depleted diet and demonstrate that eight weeks of chronic hypoxia (10%) is sufficient to induce RV hypertrophy and subsequent RV failure. Addition of a low copper diet to hypoxia did not have any further deleterious effects on right ventricular remodeling.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3988035?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0092983
URL الوصول: https://doaj.org/article/e968aad005734b4081a442f1c9d50075
رقم الأكسشن: edsdoj.968aad005734b4081a442f1c9d50075
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0092983