دورية أكاديمية
A switch in transcription and cell fate governs the onset of an epigenetically-deregulated tumor in Drosophila
| العنوان: | A switch in transcription and cell fate governs the onset of an epigenetically-deregulated tumor in Drosophila |
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| المؤلفون: | Joana Torres, Remo Monti, Ariane L Moore, Makiko Seimiya, Yanrui Jiang, Niko Beerenwinkel, Christian Beisel, Jorge V Beira, Renato Paro |
| المصدر: | eLife, Vol 7 (2018) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | dedifferentiation, embryonic-TF signature, transcription factors, epigenetic regulation, tumor onset, cell fate loss, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Tumor initiation is often linked to a loss of cellular identity. Transcriptional programs determining cellular identity are preserved by epigenetically-acting chromatin factors. Although such regulators are among the most frequently mutated genes in cancer, it is not well understood how an abnormal epigenetic condition contributes to tumor onset. In this work, we investigated the gene signature of tumors caused by disruption of the Drosophila epigenetic regulator, polyhomeotic (ph). In larval tissue ph mutant cells show a shift towards an embryonic-like signature. Using loss- and gain-of-function experiments we uncovered the embryonic transcription factor knirps (kni) as a new oncogene. The oncogenic potential of kni lies in its ability to activate JAK/STAT signaling and block differentiation. Conversely, tumor growth in ph mutant cells can be substantially reduced by overexpressing a differentiation factor. This demonstrates that epigenetically derailed tumor conditions can be reversed when targeting key players in the transcriptional network. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/32697; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.32697 |
| URL الوصول: | https://doaj.org/article/9692943910b3480fa986d0ed4f215a01 |
| رقم الأكسشن: | edsdoj.9692943910b3480fa986d0ed4f215a01 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.32697 |