دورية أكاديمية
The effect of variation of tetrahydropentagamavunon-0 concentration in lotion and emulgel formula toward acute dermal irritation study
| العنوان: | The effect of variation of tetrahydropentagamavunon-0 concentration in lotion and emulgel formula toward acute dermal irritation study |
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| المؤلفون: | Ritmaleni, Dina Suci Susilo Putri, Tia Wulandari, Abdul Karim Zulkarnain, Mimiek Murrukmihadi |
| المصدر: | Journal of Advanced Pharmaceutical Technology & Research, Vol 12, Iss 2, Pp 127-131 (2021) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Therapeutics. Pharmacology LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | emulgel, irritation, lotion, tetrahydropentagamavunon-0, Therapeutics. Pharmacology, RM1-950, Pharmacy and materia medica, RS1-441 |
| الوصف: | Tetrahydropentagamavunon-0 (THPGV-0) is a curcumin metabolite analog which known has a higher antioxidant activity than Vitamin E. This compound has been formulated in lotion as antiaging cosmetics, but the irritation effect is unknown yet. This study aims to analyze the effect of variation of THPGV-0 concentration in lotion and emulgel formula toward acute dermal irritation. The concentrations of THPGV-0 varied to 0.1%, 0.2%, and 0.4% in lotion/emulgel and tested for their physical properties such as organoleptic, homogeneity, pH, spreadability, and adhesion. Acute dermal irritation test is done in accordance with the In vivo Nonclinical Toxicity Test Guidelines by the Indonesian Food and Drug Administration (BPOM). This study showed that Primary Irritation Index (PII) value concentrations of 0.1%, 0.2%, and 0.4% THPGV-0 in lotion formula are 0.014, 0.014, and 0.028 (close to 0) and in emulgel formula are 0.08 at concentration of 0.1%, 0.33 at concentration of 0.2%, and 0.25 at concentration of 0.4%. PII of 0.1%, 0.2%, and 0.4% THPGV-0 in lotion and emulgel is included in negligible irritation response. Hence, the both of THPGV-0 formula in lotion and emulgel are considered safe to use on skin according to this study. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2231-4040 0976-2094 |
| Relation: | http://www.japtr.org/article.asp?issn=2231-4040;year=2021;volume=12;issue=2;spage=127;epage=131;aulast=Susilo; https://doaj.org/toc/2231-4040; https://doaj.org/toc/0976-2094 |
| DOI: | 10.4103/japtr.JAPTR_270_20 |
| URL الوصول: | https://doaj.org/article/96a024980c624a90bddf7ecbad9e3c4b |
| رقم الأكسشن: | edsdoj.96a024980c624a90bddf7ecbad9e3c4b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22314040 09762094 |
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| DOI: | 10.4103/japtr.JAPTR_270_20 |