دورية أكاديمية
Modulation of memory reconsolidation by adjacent novel tasks: timing defines the nature of change
| العنوان: | Modulation of memory reconsolidation by adjacent novel tasks: timing defines the nature of change |
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| المؤلفون: | Matías Nicolás Schroeder, Camila L. Fullio, Fabricio Ballarini, Diego Moncada |
| المصدر: | Communications Biology, Vol 6, Iss 1, Pp 1-9 (2023) |
| بيانات النشر: | Nature Portfolio, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | Biology (General), QH301-705.5 |
| الوصف: | Abstract Reconsolidation turns memories into a responsive state that allows their modulation until they stabilize again. This phenomenon attracted remarkable attention due to its potential impact on therapeutics and education. Recent evidence revealed that different memories undergo reconsolidation via a behavioral tagging process. Thus, their re-stabilization involves setting “reconsolidation-tags” and synthesizing plasticity-related proteins for their capture at the tagged sites. Here, we studied the possibility of affecting these fundamental mechanisms to modulate reconsolidation. Our findings, in laboratory rats, indicate that exploring a novel environment 60 min before or after memory reactivation improves spatial object recognition memory by promoting protein synthesis. Conversely, experiencing novelty immediately after reactivation impairs the reconsolidation by affecting the tags. Similar effects, but with a different optimal time window for improvement, occur in inhibitory avoidance memory. These results highlight the possibility of modulating existing memories using non-invasive interventions that selectively affect the fundamental mechanisms of behavioral tagging during their reconsolidation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2399-3642 87792362 |
| Relation: | https://doaj.org/toc/2399-3642 |
| DOI: | 10.1038/s42003-023-05666-5 |
| URL الوصول: | https://doaj.org/article/96c5fd68696d4cad82a87792362c4e0f |
| رقم الأكسشن: | edsdoj.96c5fd68696d4cad82a87792362c4e0f |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 23993642 87792362 |
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| DOI: | 10.1038/s42003-023-05666-5 |