دورية أكاديمية
Natural recombination of the torque teno canis virus within the ORF1, -2, and -3 genes and the untranslated region
| العنوان: | Natural recombination of the torque teno canis virus within the ORF1, -2, and -3 genes and the untranslated region |
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| المؤلفون: | Xuyang Wang, Jiaojiao Cheng, Yujie Jiang, Jiajun Ou, Siqi Cai, Liang Xu, Lintao Zhong, Yuqing Xiao, Xuerui Hu, Gang Lu, Liguo Yuan |
| المصدر: | Virus Research, Vol 338, Iss , Pp 199227- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Microbiology LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | Canine, Torque teno canis virus, Incidence, Recombination, China, Microbiology, QR1-502, Infectious and parasitic diseases, RC109-216 |
| الوصف: | The torque teno canis virus (TTCaV) was first reported in 2001 and it shares similarities with the known Torque teno virus (TTV) in terms of genomic organization and putative transcriptional features. It is a single-stranded DNA virus characterized by high rates of recombination and nucleotide substitution, like RNA viruses. Studies reported recombination events in torque teno virus; however, there is limited reporting of TTCaV reorganization events. This study screened fecal samples from domestic dogs in Henan Province. There was a positivity rate of 16.5% (19/115) for TTCaV. Four nearly complete TTCaV genomes, namely Canine/HeNan/4, 5, 6, and 13/2019, were obtained from the 19 positive fecal samples, whose genome sequence was obtained using gap-filling PCR. Sequence analysis revealed two unique amino acid mutation sites in the TTCaV strains, K278Q (compared with the first isolate Cf-TTV10 in Japan) and V/L268I (compared with the TTCaV strain from southern China). Subsequently, 17 near full-length TTCaV genome sequences were subjected to phylogenetic and recombination detection program analyzes. We obtained evidence supporting recombination events in the Chinese TTCaV strains. These findings suggest that mutation and recombination occurred in the three individual gene segments (ORF1, ORF2, ORF3) and the untranslated region, an area of major recombination in the Chinese TTCaV strain GX265 genome. Interestingly, the TTCaV strain (Canine/HeNan/6/2019) was a major parent involved in the genetic recombination of the GX265 strain. This study provides insights into the genetic variability and evolution of TTCaV. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1872-7492 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S0168170223001892; https://doaj.org/toc/1872-7492 |
| DOI: | 10.1016/j.virusres.2023.199227 |
| URL الوصول: | https://doaj.org/article/96e7d885654741a1b07ef57c7522b525 |
| رقم الأكسشن: | edsdoj.96e7d885654741a1b07ef57c7522b525 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18727492 |
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| DOI: | 10.1016/j.virusres.2023.199227 |