دورية أكاديمية
Expanding the Topological Space of Bioactive Peptides
| العنوان: | Expanding the Topological Space of Bioactive Peptides |
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| المؤلفون: | Jean-Louis Reymond, Tamis Darbre |
| المصدر: | CHIMIA, Vol 67, Iss 12 (2013) |
| بيانات النشر: | Swiss Chemical Society, 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Chemistry |
| مصطلحات موضوعية: | Bioactive peptides, Chemistry, QD1-999 |
| الوصف: | Naturally occurring peptides and proteins consist almost exclusively of linear or cyclic polypeptide chains. Our group explores the chemical space of peptides by redesigning their topology through the introduction of branching points in the peptide chain. Branched peptides are generally resistant to proteolysis and display remarkable biological properties by multivalency effects (peptide dendrimers) and conformational rigidity (polycyclic peptides). We review our recent progress in peptide dendrimers as enzyme models, biofilm inhibitors, antimicrobials, DNA transfection and cell-penetrating agents, and in the synthesis and characterization of bicyclic peptides as new scaffolds for drug design. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | German English French |
| تدمد: | 0009-4293 2673-2424 |
| Relation: | https://www.chimia.ch/chimia/article/view/5484; https://doaj.org/toc/0009-4293; https://doaj.org/toc/2673-2424 |
| DOI: | 10.2533/chimia.2013.864 |
| URL الوصول: | https://doaj.org/article/a9729641226f4200802a3950a1d52581 |
| رقم الأكسشن: | edsdoj.9729641226f4200802a3950a1d52581 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 00094293 26732424 |
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| DOI: | 10.2533/chimia.2013.864 |