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Tolerogenic nanoparticles mitigate the formation of anti-drug antibodies against pegylated uricase in patients with hyperuricemia

التفاصيل البيبلوغرافية
العنوان: Tolerogenic nanoparticles mitigate the formation of anti-drug antibodies against pegylated uricase in patients with hyperuricemia
المؤلفون: Earl Sands, Alan Kivitz, Wesley DeHaan, Sheldon S. Leung, Lloyd Johnston, Takashi Kei Kishimoto
المصدر: Nature Communications, Vol 13, Iss 1, Pp 1-7 (2022)
بيانات النشر: Nature Portfolio, 2022.
سنة النشر: 2022
المجموعة: LCC:Science
مصطلحات موضوعية: Science
الوصف: Anti-drug antibodies (ADA) induced by biologic drugs may hamper the efficacy of treatment, so inhibiting ADA induction is desirable. Here, in two clinical trials, the authors show that ImmTOR, previously reported to reduce drug immunogenicity in animal studies, helps mitigate ADA induced by pegylated uricase for treating patients with hyperuricemia.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2041-1723
Relation: https://doaj.org/toc/2041-1723
DOI: 10.1038/s41467-021-27945-7
URL الوصول: https://doaj.org/article/de97b0524c024b9b8277b1e7a9bd7ca8
رقم الأكسشن: edsdoj.97b0524c024b9b8277b1e7a9bd7ca8
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20411723
DOI:10.1038/s41467-021-27945-7