دورية أكاديمية
أعرض في EDS

Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate.

التفاصيل البيبلوغرافية
العنوان: Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate.
المؤلفون: Ariadne Letra, Walid Fakhouri, Renata F Fonseca, Renato Menezes, Inga Kempa, Joanne L Prasad, Toby G McHenry, Andrew C Lidral, Lina Moreno, Jeffrey C Murray, Sandra Daack-Hirsch, Mary L Marazita, Eduardo E Castilla, Baiba Lace, Ieda M Orioli, Jose M Granjeiro, Brian C Schutte, Alexandre R Vieira
المصدر: PLoS ONE, Vol 7, Iss 9, p e45441 (2012)
بيانات النشر: Public Library of Science (PLoS), 2012.
سنة النشر: 2012
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Previous evidence from tooth agenesis studies suggested IRF6 and TGFA interact. Since tooth agenesis is commonly found in individuals with cleft lip/palate (CL/P), we used four large cohorts to evaluate if IRF6 and TGFA interaction contributes to CL/P. Markers within and flanking IRF6 and TGFA genes were tested using Taqman or SYBR green chemistries for case-control analyses in 1,000 Brazilian individuals. We looked for evidence of gene-gene interaction between IRF6 and TGFA by testing if markers associated with CL/P were overtransmitted together in the case-control Brazilian dataset and in the additional family datasets. Genotypes for an additional 142 case-parent trios from South America drawn from the Latin American Collaborative Study of Congenital Malformations (ECLAMC), 154 cases from Latvia, and 8,717 individuals from several cohorts were available for replication of tests for interaction. Tgfa and Irf6 expression at critical stages during palatogenesis was analyzed in wild type and Irf6 knockout mice. Markers in and near IRF6 and TGFA were associated with CL/P in the Brazilian cohort (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3447924?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0045441
URL الوصول: https://doaj.org/article/d97b262852a745979450c8ab3e86add3
رقم الأكسشن: edsdoj.97b262852a745979450c8ab3e86add3
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0045441