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Prolonged-duration pulsed radiofrequency is associated with increased neuronal damage without further antiallodynic effects in neuropathic pain model rats

التفاصيل البيبلوغرافية
العنوان: Prolonged-duration pulsed radiofrequency is associated with increased neuronal damage without further antiallodynic effects in neuropathic pain model rats
المؤلفون: Arakawa K, Kaku R, Kurita M, Matsuoka Y, Morimatsu H
المصدر: Journal of Pain Research, Vol Volume 11, Pp 2645-2651 (2018)
بيانات النشر: Dove Medical Press, 2018.
سنة النشر: 2018
المجموعة: LCC:Medicine (General)
مصطلحات موضوعية: pulsed radiofrequency, neuropathic pain, antiallodynic effects, ATF3, HCN channels, Medicine (General), R5-920
الوصف: Kyosuke Arakawa, Ryuji Kaku, Masako Kurita, Yoshikazu Matsuoka, Hiroshi Morimatsu Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City, Okayama, Japan Aim of investigation: Pulsed radiofrequency (PRF) is a safe and effective approach for treating neuropathic pain. However, the optimal treatment conditions and analgesic mechanisms of PRF remain unclear. The aim of our study was to assess the beneficial and adverse effects of prolonged-duration PRF and the analgesic mechanisms of PRF treatment with neuropathic pain rats.Methods: Male Sprague Dawley rats received L5 spinal nerve ligation (SNL) for developing neuropathic pain. Fourteen days after L5 SNL surgery, they were divided into three groups according to duration of PRF current for 6 minutes, 12 minutes, and none. PRF current was delivered via direct visualization adjacent to the L5 dorsal root ganglion (DRG). Pain behavior was evaluated every week after L5 SNL surgery, until day 28. Seven days after PRF treatment, L5 DRG tissue was harvested to detect levels of activating translation factor 3 (ATF3; a marker of neuronal damage) and hyperpolarization-activated cyclic nucleotide (HCN)-gated cation channels (key factors in neuropathic pain) using quantitative PCR.Results: Before PRF application, withdrawal thresholds were significantly lower than at baseline and did not differ significantly between the three groups. After PRF application, withdrawal thresholds in the PRF6 and PRF12 groups were significantly increased compared to those in the sham group. However, those in the PRF6 and PRF12 groups did not differ significantly. The expression level of ATF3 mRNA in the PRF12 group was significantly higher than that in the sham group (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1178-7090
Relation: https://www.dovepress.com/prolonged-duration-pulsed-radiofrequency-is-associated-with-increased--peer-reviewed-article-JPR; https://doaj.org/toc/1178-7090
URL الوصول: https://doaj.org/article/982493f2033b4fe78a44ce0b6e02aa79
رقم الأكسشن: edsdoj.982493f2033b4fe78a44ce0b6e02aa79
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:11787090