دورية أكاديمية
Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain
| العنوان: | Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain |
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| المؤلفون: | Astrid Deryckere, Ruth Styfhals, Ali Murat Elagoz, Gregory E Maes, Eve Seuntjens |
| المصدر: | eLife, Vol 10 (2021) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | octopus vulgaris, neuronal migration, neurogenesis, transcription factors, brain development, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Cephalopods have evolved nervous systems that parallel the complexity of mammalian brains in terms of neuronal numbers and richness in behavioral output. How the cephalopod brain develops has only been described at the morphological level, and it remains unclear where the progenitor cells are located and what molecular factors drive neurogenesis. Using histological techniques, we located dividing cells, neural progenitors and postmitotic neurons in Octopus vulgaris embryos. Our results indicate that an important pool of progenitors, expressing the conserved bHLH transcription factors achaete-scute or neurogenin, is located outside the central brain cords in the lateral lips adjacent to the eyes, suggesting that newly formed neurons migrate into the cords. Lineage-tracing experiments then showed that progenitors, depending on their location in the lateral lips, generate neurons for the different lobes, similar to the squid Doryteuthis pealeii. The finding that octopus newborn neurons migrate over long distances is reminiscent of vertebrate neurogenesis and suggests it might be a fundamental strategy for large brain development. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/69161; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.69161 |
| URL الوصول: | https://doaj.org/article/986d501619964e7a84178c9c4ab9abfa |
| رقم الأكسشن: | edsdoj.986d501619964e7a84178c9c4ab9abfa |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.69161 |