دورية أكاديمية
Th17/Treg balance and macrophage polarization ratio in lower extremity arteriosclerosis obliterans
| العنوان: | Th17/Treg balance and macrophage polarization ratio in lower extremity arteriosclerosis obliterans |
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| المؤلفون: | Zhen-Zhen Li, Min Liu, Xiong-Hui He, Zhen-Dong Liu, Zhan-Xiang Xiao, Hao Qian, You-Fei Qi, Cun-Chuan Wang |
| المصدر: | Asian Pacific Journal of Tropical Biomedicine, Vol 14, Iss 3, Pp 127-136 (2024) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Arctic medicine. Tropical medicine LCC:Biology (General) |
| مصطلحات موضوعية: | lower extremity arteriosclerosis, regulatory t cells, regulatory b cells, inflammatory factors, m1 macrophages, m2 macrophages, Arctic medicine. Tropical medicine, RC955-962, Biology (General), QH301-705.5 |
| الوصف: | Objective: To explore the balance of peripheral blood T helper 17 cells/regulatory T cell (Th17/Treg) ratio and the polarization ratio of M1 and M2 macrophages in lower extremity arteriosclerosis obliterans (ASO). Methods: A rat model of lower extremity ASO was established, and blood samples from patients with lower extremity ASO before and after surgery were obtained. ELISA was used to detect interleukin 6 (IL-6), IL-10, and IL-17. Real-time RCR and Western blot analyses were used to detect Foxp3, IL-6, IL-10, and IL-17 expression. Moreover, flow cytometry was applied to detect the Th17/Treg ratio and M1/M2 ratio. Results: Compared with the control group, the iliac artery wall of ASO rats showed significant hyperplasia, and the concentrations of cholesterol and triglyceride were significantly increased (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2221-1691 2588-9222 |
| Relation: | http://www.apjtb.org/article.asp?issn=2221-1691;year=2024;volume=14;issue=3;spage=127;epage=136;aulast=Li; https://doaj.org/toc/2221-1691; https://doaj.org/toc/2588-9222 |
| DOI: | 10.4103/apjtb.apjtb_782_23 |
| URL الوصول: | https://doaj.org/article/c9872cd5b42c4f8b8e9c2f80c1d7b112 |
| رقم الأكسشن: | edsdoj.9872cd5b42c4f8b8e9c2f80c1d7b112 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22211691 25889222 |
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| DOI: | 10.4103/apjtb.apjtb_782_23 |