دورية أكاديمية
Anti-Ro52 Antibody as a Protective Factor for Pulmonary Fibrosis in Primary Sjögren's Syndrome
| العنوان: | Anti-Ro52 Antibody as a Protective Factor for Pulmonary Fibrosis in Primary Sjögren's Syndrome |
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| المؤلفون: | Defu Li, Hongbing Li, Wei Li, Tingting Zhu |
| المصدر: | Iranian Journal of Immunology, Vol 19, Iss 2, Pp 161-171 (2022) |
| بيانات النشر: | Shiraz University of Medical Sciences, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | anti-ro52 antibody, computed tomography, primary sjögren’s syndrome, pulmonary fibrosis, Biology (General), QH301-705.5 |
| الوصف: | Background: Pulmonary fibrosis is common in primary Sjögren's syndrome (pSS)-related interstitial lung disease (ILD). However, research is lacking on the diagnostic immunological examination of pSS-related pulmonary fibrosis. Particularly, the value of detecting anti-Ro52 antibody in pulmonary fibrosis is unclear. Objective: To evaluate the potential diagnostic value of anti-SSA, anti-SSB, and anti-Ro52 autoantibodies as markers of pSS-related pulmonary fibrosis. Methods: One-hundred seventy-nine patients with pSS were analyzed retrospectively at our hospital. They were divided into the fibrosis and non-fibrosis groups. Pulmonary fibrosis was classified as mild, moderate, or severe based on the patients' computed tomography (CT) findings. Laboratory examinations, including anti-SSA, anti-SSB, and anti-Ro52 antibody evaluations, were performed. The influencing factors of pulmonary fibrosis were analyzed using logistic regression. Results: Chest CT revealed pulmonary fibrosis in 45 patients with pSS (25.1%). The positive rates of anti-SSA and anti-Ro52 antibodies in the fibrosis group were lower than in the non-fibrosis group (P=0.04, P=0.001). The frequency of anti-Ro52 antibody showed no significant differences between mild-to-moderate (53.8%) and severe (47.3%) pulmonary fibrosis. The anti-Ro52 antibody was identified as a potentially protective factor against pSS (P=0.041). Conclusions: Patients with pSS and pulmonary fibrosis had a low frequency of anti-SSA and anti-Ro52 antibodies. In patients with pSS and negative anti-Ro52 antibody, a chest CT is recommended to further understand the patients' condition. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1735-1383 1735-367X |
| Relation: | https://iji.sums.ac.ir/article_48515_bc439dc62ec38405694e5df494041273.pdf; https://doaj.org/toc/1735-1383; https://doaj.org/toc/1735-367X |
| DOI: | 10.22034/iji.2022.91412.2077 |
| URL الوصول: | https://doaj.org/article/98acce106ac74938b9aa47d272979e4b |
| رقم الأكسشن: | edsdoj.98acce106ac74938b9aa47d272979e4b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17351383 1735367X |
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| DOI: | 10.22034/iji.2022.91412.2077 |