دورية أكاديمية
Evaluation of circulating tumor cells as a prognostic biomarker for early recurrence in stage II–III breast cancer patients using CytoSorter® system: a retrospective study
| العنوان: | Evaluation of circulating tumor cells as a prognostic biomarker for early recurrence in stage II–III breast cancer patients using CytoSorter® system: a retrospective study |
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| المؤلفون: | Lidan Jin, Wan-Hung Fan, Yi Luan, Meiqiong Wu, Wenhe Zhao |
| المصدر: | PeerJ, Vol 9, p e11366 (2021) |
| بيانات النشر: | PeerJ Inc., 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Biology (General) |
| مصطلحات موضوعية: | Breast cancer, Early recurrence, Circulating tumor cells, CytoSorter, Medicine, Biology (General), QH301-705.5 |
| الوصف: | Purpose Circulating tumor cells (CTCs) are known to be associated with late recurrence and poor prognosis in breast cancer (BC). Different CTC enrichment platforms have different CTC cut-off values for poor prognosis. This study aimed to evaluate whether preoperative CTCs could be a prognostic factor for early recurrence of disease in BC patients with resectable tumors, and to ascertain the CTC cut-off value for early recurrence with CytoSorter® CTC system. Methods Thirty-six stage II and III BC patients who had preoperative (pre-op) CTC detection and underwent a mastectomy or lumpectomy for curative intent between January and May 2018 were enrolled in this retrospective study. CTC detection was performed using CytoSorter® CTC system. Correlations of patients’ demographics, clinicopathological characteristics, adjuvant therapies and CTCs with relapse and survival were evaluated. Results CTCs were detected in 32 out of 36 patients before surgery. Nine patients developed relapses during follow-up, and seven of them were distant recurrence. Univariate analysis showed that CTCs were correlated with two-year recurrence free survival (RFS) and distant RFS (D-RFS) (P = 0.013 and 0.029, respectively). Two-year RFS and D-RFS were 85.2% and 88.9%, respectively, for patients with |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2167-8359 |
| Relation: | https://peerj.com/articles/11366.pdf; https://peerj.com/articles/11366/; https://doaj.org/toc/2167-8359 |
| DOI: | 10.7717/peerj.11366 |
| URL الوصول: | https://doaj.org/article/98d990e5ede84f168fb2925652c1f9fa |
| رقم الأكسشن: | edsdoj.98d990e5ede84f168fb2925652c1f9fa |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21678359 |
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| DOI: | 10.7717/peerj.11366 |