Background: A number of published reports have linked agricultural pesticides (AP) to different illnesses, one of which is cancer. Our objectives were to estimate cancer incidence and death rates in small Argentine rural towns affected by AP; and to compare these estimations with indexes from Argentina's general population. Methodology: An epidemiologic house-to-house health survey conducted by last-year medical students was implemented in 8 small rural towns of the Province of Santa Fe- Argentina (8 T), each surrounded by fields sprayed with AP. The survey covered 27,644 people, accounting for 68% of the total 8 T population. Results: Odd-ratio between cancer incidence rate in 8 T and the general population was 1.37 (P