التفاصيل البيبلوغرافية
العنوان:
Identification of KasA as the cellular target of an anti-tubercular scaffold
المؤلفون:
Katherine A. Abrahams , Chun-wa Chung , Sonja Ghidelli-Disse , Joaquín Rullas , María José Rebollo-López , Sudagar S. Gurcha , Jonathan A. G. Cox , Alfonso Mendoza , Elena Jiménez-Navarro , María Santos Martínez-Martínez , Margarete Neu , Anthony Shillings , Paul Homes , Argyrides Argyrou , Ruth Casanueva , Nicholas J. Loman , Patrick J. Moynihan , Joël Lelièvre , Carolyn Selenski , Matthew Axtman , Laurent Kremer , Marcus Bantscheff , Iñigo Angulo-Barturen , Mónica Cacho Izquierdo , Nicholas C. Cammack , Gerard Drewes , Lluis Ballell , David Barros , Gurdyal S. Besra , Robert H. Bates
المصدر:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
بيانات النشر:
Nature Portfolio, 2016.
سنة النشر:
2016
المجموعة:
LCC:Science
مصطلحات موضوعية:
Science
الوصف:
Screens for bactericidal compounds have resulted in promising anti-tubercular hits. Here, the authors analyse in detail the target of an indazole sulfonamide (GSK3011724A), and find that it has a different mode of inhibition compared to other Kas inhibitors of fatty acid biosynthesis in bacteria.
نوع الوثيقة:
article
وصف الملف:
electronic resource
اللغة:
English
تدمد:
2041-1723
Relation:
https://doaj.org/toc/2041-1723
DOI:
10.1038/ncomms12581
URL الوصول:
https://doaj.org/article/98e2a1212a5248b996b2c2ff78fce60e
رقم الأكسشن:
edsdoj.98e2a1212a5248b996b2c2ff78fce60e
قاعدة البيانات:
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