دورية أكاديمية
Gender disparity in COVID-19: Role of sex steroid hormones
| العنوان: | Gender disparity in COVID-19: Role of sex steroid hormones |
|---|---|
| المؤلفون: | Anuja Lipsa, Jyothi S Prabhu |
| المصدر: | Asian Pacific Journal of Tropical Medicine, Vol 14, Iss 1, Pp 5-9 (2021) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Arctic medicine. Tropical medicine |
| مصطلحات موضوعية: | sars-cov-2, covid-19, gender differences, steroid hormones, estrogens, androgens, Arctic medicine. Tropical medicine, RC955-962 |
| الوصف: | The emerging pandemic of COVID-19 caused by the novel pathogenic human coronavirus SARS-CoV-2 has caused significant morbidity and mortality across the globe, prompting the scientific world to search for preventive measures to interrupt the disease process. Demographic data indicates gender-based differences in COVID-19 morbidity with better outcome amongst females. Disparity in sex-dependent morbidity and mortality in COVID-19 patients may be attributed to difference in levels of sex steroid hormones -androgens and estrogens. Evidence suggests that apart from the regulation of viral host factors, immunomodulatory and cardioprotective roles exerted by estrogen and progesterone may provide protection to females against COVID-19. Exploring the underlying mechanisms and beneficial effects of these hormones as an adjuvant to existing therapy may be a step towards improving the outcomes. This article aims to review studies demonstrating the role of sex steroidal hormones in modulating SARS-CoV-2 host factors and summarize plausible biological reasons for sex-based differences seen in COVID-19 mortality. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-4146 1995-7645 20148968 |
| Relation: | http://www.apjtm.org/article.asp?issn=1995-7645;year=2021;volume=14;issue=1;spage=5;epage=9;aulast=Lipsa; https://doaj.org/toc/2352-4146 |
| DOI: | 10.4103/1995-7645.304293 |
| URL الوصول: | https://doaj.org/article/9928640fb2014896808998cadfde4d9c |
| رقم الأكسشن: | edsdoj.9928640fb2014896808998cadfde4d9c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23524146 19957645 20148968 |
|---|---|
| DOI: | 10.4103/1995-7645.304293 |